Disorders of endocrinology and metabolism are prevalent in the U.S. Addressing these difficult dilemmas requires not only the development of a critical mass of physicians to care for affected patients, but also the training of skilled researchers to develop innovative therapies and preventive measures and to delve into the basic mechanisms of diseases. The Indiana University School of Medicine is a leader in many fields of medicine. Its Section of Pediatric Endocrinology and the Division of Endocrinology and Metabolism in the Department of Medicine are both large well respected research divisions with long histories of mentoring pre-and postdoctoral trainees, including training one another's fellows in research that spans the spectrum of pediatric and adult Endocrinology. The Endocrine Scientist Training Program described here provides the opportunity for young scientists in Pediatric, Adult, or Combined Medicine-Pediatric Endocrinology training to enhance their skills in either basic laboratory, clinical, or translational research, leading to careers as independent academic researchers. After completion of their residency training, highly qualified physicians enter either the Internal Medicine, Pediatric Endocrinology, or combined Medicine- Pediatric Endocrinology fellowship, receive clinical training in the respective discipline[s), then enter this combined program in one of two tracks, the Basic Science of Endocrinology Track or the Endocrinology Clinical Research Track. These tracks provide extensive direct and didactic research training. The Basic Science of Endocrinology Track requires a series of graduate level courses, including studies in Molecular Biology, Biostatistics, and Research Ethics. The Endocrinology Clinical Research Track trainees obtain a Masters of Science in Clinical Research through our K30-funded CITE program. Trainees in the Endocrine Scientist Training Program receive two years of support for their training. Over the previous project period, this program has trained five top-notch physician scientists in the field of Endocrinology. The graduates of this program all have academic positions at major medical schools, and we anticipate that they will continu to engage in cutting-edge research to make major contributions to the health of the American people.

Public Health Relevance

The eruption of type 2 diabetes and related endocrine and metabolic problems is taking a tremendous public health toll. The elucidation of disease mechanisms and the development of new treatments for these and related conditions is critical to address these issues. This can only be done by training a critical mass of young researchers to develop and carry forward the efforts to solve these problems.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDK1-GRB-W (J3))
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Castle, Arthur
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Indiana University-Purdue University at Indianapolis
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United States
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Folsom, Lisal J; Fuqua, John S (2015) Reproductive Issues in Women with Turner Syndrome. Endocrinol Metab Clin North Am 44:723-37
Schoelwer, Melissa J; Donahue, Kelly L; Bryk, Kristina et al. (2015) Psychological assessment of mothers and their daughters at the time of diagnosis of precocious puberty. Int J Pediatr Endocrinol 2015:5
Chen, Melinda; Eugster, Erica A (2015) Central Precocious Puberty: Update on Diagnosis and Treatment. Paediatr Drugs 17:273-81
Fisher, Marisa M; Watkins, Renecia A; Blum, Janice et al. (2015) Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes. Diabetes 64:3867-72
Watson, S E; Li, Z; Tu, W et al. (2014) Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers. Pediatr Obes 9:471-7
Hannon, Tamara S; Tu, Wanzhu; Watson, Sara E et al. (2014) Morning blood pressure is associated with sleep quality in obese adolescents. J Pediatr 164:313-7
Fisher, Marisa M; Eugster, Erica A (2014) What is in our environment that effects puberty? Reprod Toxicol 44:7-14
Watson, Sara; Raj, Shekar; Eugster, Erica et al. (2014) Acute mental status change as the presenting feature of adrenal insufficiency in a patient with autoimmune polyglandular syndrome type II and stroke. J Pediatr Endocrinol Metab 27:545-8
Kono, Tatsuyoshi M; Sims, Emily K; Moss, Dan R et al. (2014) Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors. Stem Cells 32:1831-42
Hatanaka, Masayuki; Maier, Bernhard; Sims, Emily K et al. (2014) Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes 63:3404-15

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