This renewal application for T32 DK067872, Research Training in Gastroenterology at the University of Maryland, Baltimore, requests 5 yrs of funding for 3 predoctoral and 5 postdoctoral (MD, PhD, MD/PhD) trainees. Overall goals of this program are unchanged;to seek and prepare talented trainees for academic careers in Gl by offering an integrated, Interdisciplinary curriculum that emphasizes mucosal biology &immunology, cell signaling &proliferation, enteric pathogens &vaccine development, and clinical research. School of Medicine entities represented by faculty with strong NIH funding cut across departmental lines to include Medicine, Pediatrics, Surgery, Microbiology &Immunology, Biochemistry &Molecular Biology, and Epidemiology &Preventive Medicine. Broad-based training opportunities allow predoctoral trainees to obtain PhD or MD/PhD degrees and postdoctoral trainees to earn MS, MPH or PhD degrees. Four research tracks (Cell Signaling &Proliferation, Mucosal Immunology &Microbiology, Epithelial Cell Biology, and Clinical &Translational Science) are directed by accomplished senior investigators and comprised of highly productive, experienced mentors who interact both within and amongst these tracks. Trainees devote a minimum of 2 yrs in lab- or patient-based research guided by faculty with exceptional mentorship and research credentials. In its initial period of funding, the program was highly successful;all training slots were filled, trainee retention was 100%, and productivity was outstanding. Both predoctoral T32 trainees who completed training qualified for the PhD degree. Of 8 postdoctoral fellows completing training, 4 are completing clinical training and 4 are Assistant Professors pursuing basic or clinical research in academic Medicine or Pediatrics (1 supported by and another with pending NIDDK K08 awards). This T32 program is extraordinarily diverse;of 15 trainees (2005-10), 10 (66%) are women;3 (20%) are African American;and 2 (13%) are Hispanic. During the past 4 years, the program matured and grew by adding funded, productive faculty with strong mentoring credentials, and by innovation (e.g. adding Junior Faculty members, to 'mentor future mentors', and offering a Ph.D. Program for Clinicians).

Public Health Relevance

Increasingly competitive research funding and lucrative practice opportunities discourage trainees from careers in gastroenterology research. The overall goal of this program is to seek and nurture talented pre- and postdoctoral trainees preparing for academic careers in gastroenterology by offering an integrated, interdisciplinary, individualized curriculum in both basic and clinical digestive diseases-related research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK067872-08
Application #
8306336
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J3))
Program Officer
Densmore, Christine L
Project Start
2005-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
8
Fiscal Year
2012
Total Cost
$338,025
Indirect Cost
$25,182
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Richter, Taylor K S; Hazen, Tracy H; Lam, Diana et al. (2018) Temporal Variability of Escherichia coli Diversity in the Gastrointestinal Tracts of Tanzanian Children with and without Exposure to Antibiotics. mSphere 3:
Chudy-Onwugaje, Kenechukwu; Vandermeer, Fauzia; Quezada, Sandra (2018) Mimicking Abdominal Tuberculosis: Abdominal Abscess Caused by Lawsonella clevelandensis in Inflammatory Bowel Disease. Clin Gastroenterol Hepatol :
Felton, Jessica; Hu, Shien; Raufman, Jean-Pierre (2018) Targeting M3 Muscarinic Receptors for Colon Cancer Therapy. Curr Mol Pharmacol 11:184-190
Gardner, Eugene J; Lam, Vincent K; Harris, Daniel N et al. (2017) The Mobile Element Locator Tool (MELT): population-scale mobile element discovery and biology. Genome Res 27:1916-1929
Said, Anan H; Hu, Shien; Abutaleb, Ameer et al. (2017) Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J 474:647-665
Ma, Elise L; Smith, Allen D; Desai, Neemesh et al. (2017) Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice. Brain Behav Immun 66:56-69
Ramay, Fariha H; Cui, Qingping; Greenwald, Bruce D (2017) Outcomes after liquid nitrogen spray cryotherapy in Barrett's esophagus-associated high-grade dysplasia and intramucosal adenocarcinoma: 5-year follow-up. Gastrointest Endosc 86:626-632
Sieber, Karsten B; Bromley, Robin E; Dunning Hotopp, Julie C (2017) Lateral gene transfer between prokaryotes and eukaryotes. Exp Cell Res 358:421-426
Ramay, Fariha H; Greenwald, Bruce D (2017) Should endoscopic ablation therapy for Barrett's-associated neoplasia be limited to academic or tertiary referral centers? Endoscopy 49:105-107
Tang, Derek M; Urrunaga, Nathalie H; von Rosenvinge, Erik C (2016) Pseudomembranous colitis: Not always Clostridium difficile. Cleve Clin J Med 83:361-6

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