The postdoctoral Pediatric Endocrinology Training Program (PETP) at the University of Michigan is designed to recruit and provide high quality research training in one of two major tracks, Basic Science or Clinical Investigation &Epidemiology to qualified candidates. The theme of the Program is developmental programming of endocrine disorders. The program is organized to complement the established training program in clinical pediatric endocrinology for M.D.s, and for basic scientist pursuing a career in endocrine research, by providing 2 years of intensive postdoctoral training using closely-mentored research training program individually structured for each trainee. The program is actively supported by 12 faculty from 9 Departments at 4 Schools (Medicine, LS&A, Public Health and Kinesiology), all of whom have extensive research and mentoring experience. The Program also includes an extensive didactic component tailored to each trainee's educational background and research interests. Trainees in the Basic Sciences complete a 3- month course designed to expose them to a variety of state-of-the-art techniques, as well as to skills in performing hypothesis-driven, controlled research studies. Trainees in the Clinical Investigation &Epidemiology choose between Outcomes &Epidemiology or Clinical Research. They complete courses leading to either a Master of Public Health in Biostatistics &Epidemiology or a Master of Science in Clinical Research Design &Statistical Analysis. In addition to the formal curriculum, trainees attend weekly clinical and research seminars. Mentored research is supported the Medical School resources including the Centers of Integrative Genomics, Proteomics, Organogenesis and,Diabetes and the Michigan Institute for Clinical and Health Research. To optimize each trainee's potential for development of a successful academic career, trainees are required to submit abstracts to national meetings, submit a first-authored research manuscript, and apply for individual grant funding. Expansion of our Program will help alleviate the critical shortage of successful Pediatric Endocrinologists and Pediatric Physician-Scientists.

Public Health Relevance

Biomedical research faces great challenges nationwide. Academic centers need to provide an environment that allows an integrated vision of research, which in turn will deepen our understanding of biology, stimulate interdisciplinary research teams, and reshape clinical research to accelerate medical discovery and improve health. Research training is integral to the future biomedical advancement. The present proposal will train the medical doctors (MDs) and scientist (PhDs) to study the origins of hormonal disorders in children. The overarching goal of the training program is to improve children's health, prevent development and/or ameliorate severity of diseases thereby improving the health ofthe United States population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK071212-10
Application #
8706136
Study Section
Special Emphasis Panel (ZDK1-GRB-W (J3))
Program Officer
Castle, Arthur
Project Start
2005-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
$266,780
Indirect Cost
$19,090
Name
University of Michigan Ann Arbor
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Basham, Kaitlin J; Hung, Holly A; Lerario, Antonio M et al. (2016) Mouse models of adrenocortical tumors. Mol Cell Endocrinol 421:82-97
Padmanabhan, Vasantha; Veiga-Lopez, Almudena; Herkimer, Carol et al. (2015) Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep. Endocrinology 156:2678-92
Abi Salloum, B; Veiga-Lopez, A; Abbott, D H et al. (2015) Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep. Endocrinology 156:2323-37
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Singer, Kanakadurga; Eng, Donna S; Lumeng, Carey N et al. (2014) The relationship between body fat mass percentiles and inflammation in children. Obesity (Silver Spring) 22:1332-6
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Veiga-Lopez, A; Beckett, E M; Abi Salloum, B et al. (2014) Developmental programming: prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep. Toxicol Appl Pharmacol 279:119-28
Parlee, Sebastian D; Simon, Becky R; Scheller, Erica L et al. (2014) Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females. Endocrinology 155:1313-26
Gregg, Brigid; Elghazi, Lynda; Alejandro, Emilyn U et al. (2014) Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors. Diabetologia 57:2566-75
Alejandro, Emilyn U; Gregg, Brigid; Wallen, Taylor et al. (2014) Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring. J Clin Invest 124:4395-410

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