This application seeks continued support for a Pediatric Gastroenterology Training program at the University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC.
Our specific aim i s to train pediatric physician- scientists and non-physician scientists for independent academic careers investigating topics relevant to gastrointestinal, pancreatic and hepatic diseases in infancy and childhood. A key goal of the proposed program is to prepare each trainee to transition to their own mentored scholar award (K-series). Our program includes two years of clinical or laboratory research for physician-scientists and non-physician scientists. The research years will be supervised by a committee of faculty selected from the University of Pittsburgh academic community based on their history of productivity, their interest in research in gastroenterology or hepatology, their history of obtaining funding and their commitment to training. In addition to providing a research environment for trainees, members of the faculty will also serve on individually tailored Project Committees, which will oversee, evaluate and guide the scientific and intellectual progress of each trainee. Trainees will work side-by-side with other MD, PhD and MD/PhD predoctoral and postdoctoral trainees. We have now trained four physician-scientists in this environment. The two that graduated are in academic programs and continuing to pursue research careers. The two that will graduate in June 2010 have accepted positions at academic institutions. In the past grant period, the Department of Pediatrics including the Division of Pediatric Gastroenterology moved into a new 300,000 square foot research building adjacent to the new Children's Hospital confirming the commitment of the Institution to fostering research. The institutional commitment to research, the dedication of our faculty to mentor young scientists and the excellent fellow candidates attracted to our program makes this an outstanding environment to successfully train the next generation of scientists in Pediatric Gastroenterology.

Public Health Relevance

The goal of this application is to train pediatric physician-scientists and non-physician scientists for independent academic careers investigating topics relevant to gastrointestinal, pancreatic and hepatic diseases in infancy and childhood. NOTE: The criteria scores and the critiques given below were provided by the reviewers assigned to this application. These do not necessarily reflect the positions of the reviewers at the close of the group discussion or the final majority opinion of the group, although the reviewers were asked to amend their criteria scores and critiques if their positions changed during the discussion. Please note that the criteria scores are not averaged in arriving at the final overall impact scores. If the reviewers have not changed their criteria scores after the discussion, those shown in the critiques may reflect the opinion of the reviewers before the meeting. The Resume and other initial sections of the summary statement are the authoritative representations of the final outcome of the group discussion. If there is any discrepancy between the reviewers'commentaries and the priority/impact score on the face page of this summary statement, the priority/impact score should be considered the most accurate representation of the final outcome of the group discussion

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (J2))
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
O'Donnell, Brighid M; Mackie, Timothy D; Brodsky, Jeffrey L (2017) Linking chanelopathies with endoplasmic reticulum associated degradation. Channels (Austin) 11:499-501
O'Donnell, Brighid M; Mackie, Timothy D; Subramanya, Arohan R et al. (2017) Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome. J Biol Chem 292:12813-12827
Le, Tianming; Eisses, John F; Lemon, Kathryn L et al. (2015) Intraductal infusion of taurocholate followed by distal common bile duct ligation leads to a severe necrotic model of pancreatitis in mice. Pancreas 44:493-9
Eisses, John F; Criscimanna, Angela; Dionise, Zachary R et al. (2015) Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol 185:3304-15
Srinath, Arvind I; Youk, Ada O; Bielefeldt, Klaus (2014) Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin? Dig Dis Sci 59:1307-15
Clark, Jeffrey G; Srinath, Arvind I; Youk, Ada O et al. (2014) Predictors of depression in youth with Crohn disease. J Pediatr Gastroenterol Nutr 58:569-73
Lewarchik, Christopher M; Orabi, Abrahim I; Jin, Shunqian et al. (2014) The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury. Am J Physiol Gastrointest Liver Physiol 307:G574-81
Szigethy, Eva M; Youk, Ada O; Benhayon, David et al. (2014) Depression subtypes in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr 58:574-81
Eisses, John F; Davis, Amy W; Tosun, Akif Burak et al. (2014) A computer-based automated algorithm for assessing acinar cell loss after experimental pancreatitis. PLoS One 9:e110220
Ghouse, Raafe; Chu, Andrew; Wang, Yan et al. (2014) Mysteries of ?1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease. Dis Model Mech 7:411-9

Showing the most recent 10 out of 18 publications