Abstract

This is a revised renewal application for years 11-16 of the University of Florida ?Training Program in Regenerative Medicine? T32 Institutional Research Training Grant DK074367. The current renewal application seeks an additional five years of funding for a multi-disciplinary training program in Stem Cell Biology & Regenerative Medicine to support fuor pre-doctoral trainees and two post-doctoral fellows. This represents the addition of one additional pre-doctoral training slot over our current grant award, as recommended by the previous reviewers. The goal of this training program is to produce independent investigators capable of sustaining productive research programs studying the molecular and cellular aspects of stem cell biology and the use of stem cell products in patient care. Stem cell biology, outside of hematopoietic stem cells, is a relatively new area with great potential for development of novel treatments for both human and animal diseases ? Regenerative Medicine. With the emerging interest in stem cell biology and Regenerative Medicine, the need for trained researchers cannot be overstated.

Public Health Relevance

This is a revised renewal application to continue supporting research training in the area of hematopoietic stem cell biology and regenerative medicine. The goal is to train new scientists to help design cell based therapies to treat a wide variety of human disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK074367-12
Application #
9734040
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Spruance, Victoria Marie
Project Start
2006-07-01
Project End
2023-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Genetics
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Hamazaki, Takashi; El Rouby, Nihal; Fredette, Natalie C et al. (2017) Concise Review: Induced Pluripotent Stem Cell Research in the Era of Precision Medicine. Stem Cells 35:545-550
Gilkes, J A; Bloom, M D; Heldermon, C D (2016) Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10. Gene Ther 23:263-71
Pi, Liya; Jorgensen, Marda; Oh, Seh-Hoon et al. (2015) A disintegrin and metalloprotease with thrombospondin type I motif 7: a new protease for connective tissue growth factor in hepatic progenitor/oval cell niche. Am J Pathol 185:1552-63
Pi, Liya; Robinson, Paulette M; Jorgensen, Marda et al. (2015) Connective tissue growth factor and integrin ?v?6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice. Hepatology 61:678-91
Cheng, Xiaodong; Byrne, Michael; Brown, Kevin D et al. (2015) PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice. Blood 126:1585-94
Lopez, David; Scott, Edward W (2015) Generation of axolotl hematopoietic chimeras. J Biol Methods 2:
Maden, Malcolm; Avila, Daima; Roy, Molly et al. (2015) Tissue specific reactions to positional discontinuities in the regenerating axolotl limb. Regeneration (Oxf) 2:137-147
Lopez, David; Lin, Li; Monaghan, James R et al. (2014) Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl. Blood 124:1232-41
Cogle, Christopher R; Goldman, Devorah C; Madlambayan, Gerard J et al. (2014) Functional integration of acute myeloid leukemia into the vascular niche. Leukemia 28:1978-1987
Silver, Daniel J; Siebzehnrubl, Florian A; Schildts, Michela J et al. (2013) Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci 33:15603-17

Showing the most recent 10 out of 21 publications