This is a revised application for a training program in Endocrine, Metabolic, and Perinatal Basis of Chronic Kidney Disease to support 3 predoctoral trainees. The overall goal is to produce top quality independent investigators with a strong translational approach who can develop and sustain outstanding research programs. The training faculty consists of 23 mentors from 6 departments in the Colleges of Medicine, Pharmacy, and Veterinary Medicine. The faculty consists of basic scientists and clinician-scientists with a wide range of interests and expertise, much of which is focused on endocrine-cardiorenal interactions. The predoctoral trainees will be recruited and trained through the College of Medicine's Interdisciplinary Program in Biomedical Sciences (IDP). The pool of trainee grant eligible candidates from the entire US has averaged 170/year during the past 3 years with ~ 50/year entering the training program. These trainees enter with an average combined verbal plus quantitative GRE scores of ~1200-1250, and undergraduate GPAs of ~3.5. The IDP provides comprehensive lecture and laboratory courses as well as laboratory rotations and advanced course work in specialized disciplines. Subsequent training focuses on independent research in the laboratory of choice as well as supplemental training in development of communication skills and ethical aspects of research. A core curriculum for this training program has been designed with the intent of providing the students with the knowledge appropriate for researchers working on the endocrine, metabolic, and prenatal basis of chronic kidney disease. The predoctoral training usually takes ~ 5 years with the first year provided by the respective college, an average of 3-4 years support anticipated from the training grant and additional funds supplied by the mentors research grants.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK076541-05
Application #
8289613
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
2008-06-01
Project End
2013-11-30
Budget Start
2012-06-01
Budget End
2013-11-30
Support Year
5
Fiscal Year
2012
Total Cost
$68,229
Indirect Cost
$4,357
Name
University of Florida
Department
Physiology
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
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Chang, Eileen I; Zárate, Miguel A; Rabaglino, Maria B et al. (2016) Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex. Physiol Rep 4:
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Chang, Eileen I; Wood, Charles E (2015) Ketamine Attenuates the ACTH Response to Hypoxia in Late-Gestation Ovine Fetus. Neonatology 107:249-55
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Moningka, Natasha C; Cunningham Jr, Mark W; Sterling, Myrline et al. (2013) Effects of voluntary wheel running on the kidney at baseline and after ischaemia-reperfusion-induced acute kidney injury: a strain difference comparison. J Physiol 591:1313-24
Moningka, Natasha C; Tsarova, Tatsiana; Sasser, Jennifer M et al. (2012) Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade. Nephrol Dial Transplant 27:913-20

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