This is a revised application for a training program in Endocrine, Metabolic, and Perinatal Basis of Chronic Kidney Disease to support 3 predoctoral trainees. The overall goal is to produce top quality independent investigators with a strong translational approach who can develop and sustain outstanding research programs. The training faculty consists of 23 mentors from 6 departments in the Colleges of Medicine, Pharmacy, and Veterinary Medicine. The faculty consists of basic scientists and clinician-scientists with a wide range of interests and expertise, much of which is focused on endocrine-cardiorenal interactions. The predoctoral trainees will be recruited and trained through the College of Medicine's Interdisciplinary Program in Biomedical Sciences (IDP). The pool of trainee grant eligible candidates from the entire US has averaged 170/year during the past 3 years with ~ 50/year entering the training program. These trainees enter with an average combined verbal plus quantitative GRE scores of ~1200-1250, and undergraduate GPAs of ~3.5. The IDP provides comprehensive lecture and laboratory courses as well as laboratory rotations and advanced course work in specialized disciplines. Subsequent training focuses on independent research in the laboratory of choice as well as supplemental training in development of communication skills and ethical aspects of research. A core curriculum for this training program has been designed with the intent of providing the students with the knowledge appropriate for researchers working on the endocrine, metabolic, and prenatal basis of chronic kidney disease. The predoctoral training usually takes ~ 5 years with the first year provided by the respective college, an average of 3-4 years support anticipated from the training grant and additional funds supplied by the mentors research grants.
|Wood, Charles E; Rabaglino, Maria Belen; Richards, Elaine et al. (2014) Transcriptomics of the fetal hypothalamic response to brachiocephalic occlusion and estradiol treatment. Physiol Genomics 46:523-32|
|Moningka, Natasha C; Cunningham Jr, Mark W; Sterling, Myrline et al. (2013) Effects of voluntary wheel running on the kidney at baseline and after ischaemia-reperfusion-induced acute kidney injury: a strain difference comparison. J Physiol 591:1313-24|
|Moningka, Natasha C; Tsarova, Tatsiana; Sasser, Jennifer M et al. (2012) Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade. Nephrol Dial Transplant 27:913-20|
|Chen, Gin-Fu; Moningka, Natasha C; Sasser, Jennifer M et al. (2012) Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat. Am J Nephrol 35:40-8|
|Moningka, Natasha C; Sasser, Jennifer M; Croker, Byron et al. (2011) Protection against age-dependent renal injury in the F344xBrown Norway male rat is associated with maintained nitric oxide synthase. Mech Ageing Dev 132:1-7|
|Moningka, Natasha C; Sindler, Amy L; Muller-Delp, Judy M et al. (2011) Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat. J Physiol 589:6129-38|