The goal of the Childhood Diabetes Clinical &Molecular Research Training Program (CDCMRT) is to train PhD fellows and MD pediatric endocrinology fellows for academic research careers in childhood obesity, fitness and diabetes. The program emphasizes research on type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and often leading to overt diabetes, has become a major health problem in children. The fellow will have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or a career in whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, hyperandrogenemia and the metabolic syndrome in an ethnically diverse population. Objectives include 1) to establish a high quality and productive research project, 2) to develop a progressive record of publication in respected research journals, 3) to obtain extramural grant funding during the fellowship, and 4) to have a minimum of 50% of the graduates of this program pursue an academic career in childhood diabetes, insulin resistance and obesity research. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Clinical Investigator Preparatory Program (CIPP) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. These demographics and accomplishments, together with the recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training have prompted us to seek funding for this program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given these opportunities, the CDCMRT program can provide trainees with a comprehensive mentored research training experience that will prepare them for successful research careers in childhood diabetes, insulin resistance and obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK077586-04
Application #
8090435
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2008-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
4
Fiscal Year
2011
Total Cost
$122,541
Indirect Cost
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kanner, Lauren Amanda; Klein, Jason; Gaffar, Majida et al. (2017) New-Onset Isolated Asymptomatic Papilledema in Two Patients Treated With Recombinant Growth Hormone. Clin Pediatr (Phila) :9922817698808
Pollock, Allison J; Seibert, Tasa S; Salvatori, Cristiana et al. (2017) Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. Horm Res Paediatr 87:123-129
Pollock, Allison J; Seibert, Tasa; Allen, David B (2016) Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth. J Pediatr 173:232-4
Pollock, Allison J; Allen, David B; Wiebe, Donald et al. (2016) Development of filter paper hemoglobin A1c assay applicable to newborn screening. Clin Chim Acta 457:24-6
Pollock, Allison J; Moreno, Megan A; Bekx, M Tracy et al. (2016) Online Resources for Pediatric Type 1 Diabetes: What Adolescents Want. J Diabetes Sci Technol 10:1419-1420
Pollock, Allison J; Hitt, Stacy L; Stier, Michael A et al. (2015) Eosinophilic Endomyocarditis: A Rare Case of Neonatal Mortality. AJP Rep 5:e150-2
Wolfgram, Peter M; Allen, David B (2015) Factors influencing growth effects of inhaled corticosteroids in children. J Allergy Clin Immunol 136:1711-1712.e2
Pollock, Allison J; Fost, Norman; Allen, David B (2015) Growth attenuation therapy: practice and perspectives of paediatric endocrinologists. Arch Dis Child 100:1185
Rehm, Jennifer L; Wolfgram, Peter M; Hernando, Diego et al. (2015) Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women. Eur Radiol 25:2921-30
Wolfgram, Peter M; Connor, Ellen L; Rehm, Jennifer L et al. (2015) In Nonobese Girls, Waist Circumference as a Predictor of Insulin Resistance Is Comparable to MRI Fat Measures and Superior to BMI. Horm Res Paediatr 84:258-65

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