We propose a training program designed to attract and train pre- and post-doctoral scientists in research on the roles of bioenergetics and oxidative stress in the pathophysiology of metabolic syndrome. The goals of this training program are to nurture talented young individuals in the areas of basic research and clinical investigation, to teach them to design and perform successful research projects, and to give them a solid background in the ethics and methods of scientific research. The objective of this fellowship is to increase the focus of research on metabolic syndrome, bioenergetics, and oxidative stress within MUSC and to train individuals to become independent investigators and academic faculty with an interest in the area of metabolic syndrome and related diseases. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants. The training program is designed to provide experience for two and three years, respectively, of full-time effort for postdoctoral and predoctoral fellows working with a group of talented faculty mentors. Research projects are concentrated in the areas of bioenergetics and oxidative stress as they relate to the various aspects of the metabolic syndrome, including insulin resistance, diabetes, obesity, dyslipidemia, hepatic steatosis, inflammation, and consequent tissue injury, especially to the liver and kidney. Weekly conferences with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at in-house departmental seminars and submit abstracts to national meetings. Predoctoral students will matriculate through the College of Graduate Studies and follow the course of study for the PhD in Biomedical Sciences. After receiving basic training in cell, molecular, and organismal biology, predoctoral trainees will participate in a graduate course on """"""""Bioenergetics and Oxidative Stress in the Metabolic Syndrome(s)""""""""together with postdoctoral trainees. All trainees will attend required courses in methods in clinical research, responsible conduct of research, and statistics. Trainees will also be offered graduate-level courses on numerous research topics at MUSC to enhance their training experience.

Public Health Relevance

Our program focuses on research training in bioenergetics and oxidative stress related to metabolic syndrome, which is a constellation of clinical conditions, most notably obesity, insulin resistance, Type-2 diabetes, dyslipemia, hypertension, and nonalcoholic fatty liver disease. Affecting about 50 million in the US, metabolic syndrome predisposes atherosclerosis, coronary heart disease, stroke and other diseases, so treatment of metabolic syndrome and its manifestations is key to decreasing morbidity and mortality from these diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Pharmacy
United States
Zip Code
DeHart, David N; Lemasters, John J; Maldonado, Eduardo N (2018) Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov 23:23-33
DeHart, David N; Fang, Diana; Heslop, Kareem et al. (2018) Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol 148:155-162
Gibbs, Whitney S; Garrett, Sara M; Beeson, Craig C et al. (2018) Identification of dual mechanisms mediating 5-hydroxytryptamine receptor 1F-induced mitochondrial biogenesis. Am J Physiol Renal Physiol 314:F260-F268
Pleasant-Jenkins, Dorea; Reese, Charles; Chinnakkannu, Panneerselvem et al. (2017) Reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin-1 surrogate peptide. Lab Invest 97:370-382
Harmon, Jennifer L; Gibbs, Whitney S; Whitaker, Ryan M et al. (2017) Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury. J Neurotrauma 34:487-494
Maldonado, Eduardo N; DeHart, David N; Patnaik, Jyoti et al. (2017) ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator. J Biol Chem 292:16969
Bhargava, Pallavi; Schnellmann, Rick G (2017) Mitochondrial energetics in the kidney. Nat Rev Nephrol 13:629-646
Gibbs, Whitney S; Weber, Rachel A; Schnellmann, Rick G et al. (2016) Disrupted mitochondrial genes and inflammation following stroke. Life Sci 166:139-148
Harmon, Jennifer L; Wills, Lauren P; McOmish, Caitlin E et al. (2016) 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. J Pharmacol Exp Ther 357:1-9
Garrett, Sara M; Whitaker, Ryan M; Beeson, Craig C et al. (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350:257-64

Showing the most recent 10 out of 12 publications