This proposal is a new application of a National Research Service Award for Kidney Research Training at Northwestern University Feinberg School of Medicine. This request responds to the urgent need for Nephrology research training by providing rigorous mentored and inspired research experiences in both clinical and basic disciplines. The program builds on the strengths of current training opportunities in basic, clinical, translational, public health and health services research and engages a pool of talented investigators within the adult and pediatric divisions of Nephrology at Northwestern Memorial Hospital and Children's Lurie Hospital, the division of transplant medicine and numerous other Departments across the Northwestern campus. This first time proposal request comes at a time of substantial and sustained growth in the Divisions of Nephrology and the research enterprise of the Feinberg School of Medicine. The long-term, overriding, goal of this training program is to nurture bright, enthusiastic, well-trained, academically-oriented M.D.s, M.D.-PhD's and Ph.D's in pursuit of a career in Kidney Disease Investigation. Our program will provide a `team approach' to mentorship, which will be provided by both clinical and basic investigators who have expertise across multiple disciplines. This approach will provide trainees with essential skills needed to develop the most innovative, successful and significant kidney research programs in the ever- evolving scientific environment, which depends heavily on ability of investigators to develop multi-disciplinary collaborations. The specific objectives of the training grant are: 1) to develop clinical and basic research scientists, who will ultimately be capable of independently performing hypothesis-driven research that addresses the needs of our target patient population; 2) to provide stipend support and protected time for research trainees; 3) to provide both basic and clinical science trainees a rigorous base of classroom and interactive study in the disciplines necessary for successfully conducting research relevant to disease etiology, pathogenesis and outcomes and for the development of innovative care to patients with all forms of kidney disease and/or replacement therapy; 5) to establish an ongoing evaluation process; 6) to provide exposure to both basic and clinical research through a co-mentorship process 7) to train pediatric and adult nephrologists side-by-side to improve understanding of kidney disease initiation, progression and transition.

Public Health Relevance

There is an urgent need to train highly skilled M.D. and Ph.D. investigators to conduct research leading to improved care for patients living with kidney disease. While the shortage of physician-scientists affects all areas of academic medicine, there is a particular urgency and crisis impacting fellowship training in nephrology. The long-term, overriding, goal of the Northwestern University Scientist Training Program in Kidney Disease (NUKIDs) is to nurture bright, motivated, enthusiastic, well-trained academically-oriented M.D.s, MD-PhDs and Ph.D's in their pursuit of careers in Kidney Research, developing the next generation of academic leaders

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
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Rankin, Tracy L
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Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
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Ide, Shintaro; Finer, Gal; Maezawa, Yoshiro et al. (2018) Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. J Am Soc Nephrol 29:2795-2808
Souma, Tomokazu; Thomson, Benjamin R; Heinen, Stefan et al. (2018) Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A 115:1298-1303
Kenig-Kozlovsky, Yael; Scott, Rizaldy P; Onay, Tuncer et al. (2018) Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol 29:1097-1107