Predoctoral training in medical imaging is a large and vigorous effort at Duke University, drawing chiefly on the resources of the Departments of Biomedical Engineering and Radiology. The program has 68 current students and it has granted over 100 PhD's in the field over the past 35 years. Both Departments are poised for significant growth in medical imaging in the next 5 years. In addition, we propose a new emphasis on molecular imaging during the proposed funding period, based on the establishment of a new Center for Molecular and Biomolecular Imaging at Duke University. The Center will hire at least 3 new imaging faculty in molecular imaging in the next 1-2 years and establish several new imaging courses and workshops. We propose to integrate these new educational and research efforts into the Medical Imaging Training Program (MITP). The 22 current training faculty provide broad research opportunities with research interests in computer-aided diagnosis, x-ray, CT, MRI, ultrasound, nuclear medicine, optical imaging methods, biomolecular imaging, and medical physics. Through the MITP, we supported 4 students Year 1 and 8 students each year thereafter. We have successfully recruited two minority students as trainees. Trainees are funded in the first two years of graduate study and undertake a comprehensive curriculum providing initially broad training in medical physics and instrumentation followed by increasingly focused coursework in the student's area of specialization. The development of all of the trainees as independent and successful researchers is strongly evidenced by their publication records and their receipt of competitive education funding awards. Accomplishments of this program include: 1) the development and continued availability of a Radiology in Practice course which pairs students with a series of practicing radiologists in various specialties;2) a broad, continuing exposure to issues related to Responsible Conduct in Research, including two-workshops on ethics related specifically to Biomedical Engineering;3) a year-long continuing Medical Imaging Seminar Series, taken by second year students, that exposes students the wide medical imaging research activities at Duke and other institutions;4) sponsored student travel to scientific meetings on medical imaging;5) development of two new courses;6) the development of an Internship Program;7) 72 trainee publications;and 8) development of the Emerging Methods in Medical Imaging program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB001040-10
Application #
8499300
Study Section
Special Emphasis Panel (ZEB1-OSR-E (M1))
Program Officer
Baird, Richard A
Project Start
2003-07-15
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$244,083
Indirect Cost
$14,522
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Yuan, Hsiangkuo; Wilson, Christy M; Xia, Jun et al. (2014) Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Nanoscale 6:4078-82
Chowdhury, Shwetadwip; Izatt, Joseph (2014) Structured illumination diffraction phase microscopy for broadband, subdiffraction resolution, quantitative phase imaging. Opt Lett 39:1015-8
Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, Tuan (2014) Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering. J Phys Chem C Nanomater Interfaces 118:3708-3715
Dibb, Russell; Li, Wei; Cofer, Gary et al. (2014) Microstructural origins of gadolinium-enhanced susceptibility contrast and anisotropy. Magn Reson Med 72:1702-11
Lindsey, Brooks D; Smith, Stephen W (2014) Refraction correction in 3D transcranial ultrasound imaging. Ultrason Imaging 36:35-54
Lindsey, Brooks D; Nicoletto, Heather A; Bennett, Ellen R et al. (2014) 3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement. Ultrasound Med Biol 40:90-101
Ngo, Hoan Thanh; Wang, Hsin-Neng; Fales, Andrew M et al. (2013) Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip. Anal Chem 85:6378-83
Lindsey, Brooks D; Smith, Stephen W (2013) Pitch-catch phase aberration correction of multiple isoplanatic patches for 3-D transcranial ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control 60:463-80
Lindsey, Brooks D; Nicoletto, Heather A; Bennett, Ellen R et al. (2013) Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows. Ultrasound Med Biol 39:721-34
Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, Tuan (2013) Cell-penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy. Mol Pharm 10:2291-8

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