Cardiovascular disease is the major cause of morbidity and mortality in the United States. In fact, 1 in 3 deaths in 2005 was due to cardiovascular disease (CVD), most of those due to coronary heart disease, and one in 3 Americans carry a diagnosis of CVD. The need for improved noninvasive methods to detect early cardiovascular disease and to help manage patients with chronic disease has therefore never been as critical. In addition, the development of molecular cardiovascular imaging is a recent advance that makes noninvasive imaging even more promising. The number of physicians who have in-depth training and expertise in the physics, engineering, molecular, and translational applications in cardiovascular imaging remains limited. The University of Virginia is one of a handful of centers in the U.S. that have high-level clinical, physics, engineering, and molecular expertise in all 4 cardiovascular imaging modalities as well as a track record of training physicians in all. The purpose of this grant renewal proposal is to continue the research training program that provides comprehensive training in all four cardiovascular imaging modalities, including molecular imaging. This program provides trainees with outstanding opportunities to interact with imaging physicists and engineers who together offer the promise of improvements in the clinical applications of newer technologies. Each trainee is mentored by both a PhD scientist and a MD clinician scientist to ensure an integrated training experience. The goal of the training is to develop the next generation of academic clinician investigators in cardiovascular imaging who can interact across basic and clinical imaging science. Trainees undergo a rigorous 2-year research training program following a 2 -year clinical cardiovascular training program completed at the University of Virginia or a 3-year program completed at another institution. Two fellows per year enter the program such that there are 4 fellows enrolled at any one time. A complete didactic program is offered including instruction in imaging physics and engineering, molecular imaging, statistics, epidemiology, clinical research methodology, and medical ethics. Research training is comprehensive and combines clinical and basic cardiovascular imaging research for each trainee.

Public Health Relevance

One in 3 deaths in the U.S. is due to cardiovascular disease, most due to coronary heart disease. The need for improved noninvasive methods to detect early disease and to help manage chronic disease has never been as critical. Training academic clinician investigators in the physics, engineering, molecular and translational research approaches to cardiovascular imaging is essential to future improvements.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZEB1-OSR-D (J1))
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Baird, Richard A
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University of Virginia
Internal Medicine/Medicine
Schools of Medicine
United States
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Hamirani, Yasmin S; Kramer, Christopher M (2014) Cardiac MRI assessment of myocardial perfusion. Future Cardiol 10:349-58
Salerno, Michael; Taylor, Angela; Yang, Yang et al. (2014) Adenosine stress cardiovascular magnetic resonance with variable-density spiral pulse sequences accurately detects coronary artery disease: initial clinical evaluation. Circ Cardiovasc Imaging 7:639-46
Kuruvilla, Sujith; Adenaw, Nebiyu; Katwal, Arabindra B et al. (2014) Late gadolinium enhancement on cardiac magnetic resonance predicts adverse cardiovascular outcomes in nonischemic cardiomyopathy: a systematic review and meta-analysis. Circ Cardiovasc Imaging 7:250-8
Salerno, Michael; Janardhanan, Rajesh; Jiji, Ronny S et al. (2013) Comparison of methods for determining the partition coefficient of gadolinium in the myocardium using T1 mapping. J Magn Reson Imaging 38:217-24
Jiji, Ronny S; Pollak, Amy W; Epstein, Frederick H et al. (2013) Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease. J Cardiovasc Magn Reson 15:14
Kuruvilla, Sujith; Kramer, Christopher M (2013) Coronary microvascular dysfunction in women: an overview of diagnostic strategies. Expert Rev Cardiovasc Ther 11:1515-25
Hamirani, Yasmin S; Kramer, Christopher M (2013) Advances in stress cardiac MRI and computed tomography. Future Cardiol 9:681-95
Bourque, Jamieson M; Patel, Chetan A; Ali, Mohamed M et al. (2013) Prevalence and predictors of ischemia and outcomes in outpatients with diabetes mellitus referred for single-photon emission computed tomography myocardial perfusion imaging. Circ Cardiovasc Imaging 6:466-77
Lopez, David; Kramer, Christopher M (2013) Oxygenation and flow in the limbs: Novel methods to characterize peripheral artery disease. Curr Cardiovasc Imaging Rep 6:150-157
Bourque, Jamieson M; Schietinger, Brian J; Kennedy, Jamie L et al. (2012) Usefulness of cardiovascular magnetic resonance imaging of the superficial femoral artery for screening patients with diabetes mellitus for atherosclerosis. Am J Cardiol 110:50-6

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