Cardiovascular disease is the major cause of morbidity and mortality in the United States. In fact, 1 in 3 deaths in 2005 was due to cardiovascular disease (CVD), most of those due to coronary heart disease, and one in 3 Americans carry a diagnosis of CVD. The need for improved noninvasive methods to detect early cardiovascular disease and to help manage patients with chronic disease has therefore never been as critical. In addition, the development of molecular cardiovascular imaging is a recent advance that makes noninvasive imaging even more promising. The number of physicians who have in-depth training and expertise in the physics, engineering, molecular, and translational applications in cardiovascular imaging remains limited. The University of Virginia is one of a handful of centers in the U.S. that have high-level clinical, physics, engineering, and molecular expertise in all 4 cardiovascular imaging modalities as well as a track record of training physicians in all. The purpose of this grant renewal proposal is to continue the research training program that provides comprehensive training in all four cardiovascular imaging modalities, including molecular imaging. This program provides trainees with outstanding opportunities to interact with imaging physicists and engineers who together offer the promise of improvements in the clinical applications of newer technologies. Each trainee is mentored by both a PhD scientist and a MD clinician scientist to ensure an integrated training experience. The goal of the training is to develop the next generation of academic clinician investigators in cardiovascular imaging who can interact across basic and clinical imaging science. Trainees undergo a rigorous 2-year research training program following a 2 -year clinical cardiovascular training program completed at the University of Virginia or a 3-year program completed at another institution. Two fellows per year enter the program such that there are 4 fellows enrolled at any one time. A complete didactic program is offered including instruction in imaging physics and engineering, molecular imaging, statistics, epidemiology, clinical research methodology, and medical ethics. Research training is comprehensive and combines clinical and basic cardiovascular imaging research for each trainee.

Public Health Relevance

One in 3 deaths in the U.S. is due to cardiovascular disease, most due to coronary heart disease. The need for improved noninvasive methods to detect early disease and to help manage chronic disease has never been as critical. Training academic clinician investigators in the physics, engineering, molecular and translational research approaches to cardiovascular imaging is essential to future improvements.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZEB1-OSR-D (J1))
Program Officer
Baird, Richard A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Virginia
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Coleman, G Cameron; Shaw, Peter W; Balfour Jr, Pelbreton C et al. (2017) Prognostic Value of Myocardial Scarring on CMR in Patients With Cardiac Sarcoidosis. JACC Cardiovasc Imaging 10:411-420
Balfour Jr, Pelbreton C; Gonzalez, Jorge A; Kramer, Christopher M (2017) Non-invasive assessment of low- and intermediate-risk patients with chest pain. Trends Cardiovasc Med 27:182-189
Auger, Daniel A; Bilchick, Kenneth C; Gonzalez, Jorge A et al. (2017) Imaging left-ventricular mechanical activation in heart failure patients using cine DENSE MRI: Validation and implications for cardiac resynchronization therapy. J Magn Reson Imaging 46:887-896
Lopez, David; Pan, Jonathan A; Pollak, Peter M et al. (2017) Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini-pig model. NMR Biomed 30:
Hamirani, Yasmin S; Kundu, Bijoy K; Zhong, Min et al. (2016) Noninvasive Detection of Early Metabolic Left Ventricular Remodeling in Systemic Hypertension. Cardiology 133:157-62
Bilchick, Kenneth C; Mealor, Augustus; Gonzalez, Jorge et al. (2016) Effectiveness of integrating delayed computed tomography angiography imaging for left atrial appendage thrombus exclusion into the care of patients undergoing ablation of atrial fibrillation. Heart Rhythm 13:12-9
Hamirani, Yasmin; Fanous, Ibrahim; Kramer, Christopher M et al. (2016) Anthracycline- and trastuzumab-induced cardiotoxicity: a retrospective study. Med Oncol 33:82
Yang, Yang; Kramer, Christopher M; Shaw, Peter W et al. (2016) First-pass myocardial perfusion imaging with whole-heart coverage using L1-SPIRiT accelerated variable density spiral trajectories. Magn Reson Med 76:1375-1387
Chow, Kelvin; Yang, Yang; Shaw, Peter et al. (2016) Robust free-breathing SASHA T1 mapping with high-contrast image registration. J Cardiovasc Magn Reson 18:47
Mehta, Bhairav B; Auger, Daniel A; Gonzalez, Jorge A et al. (2015) Detection of elevated right ventricular extracellular volume in pulmonary hypertension using Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGIE) cardiovascular magnetic resonance. J Cardiovasc Magn Reson 17:110

Showing the most recent 10 out of 57 publications