i This proposal describes our "Integrated Engineering and Rehabilitation Training" program that produces biomedical Ph.D. graduates who combine an unquestioned expertise in neural stimulation and general rehabilitation engineering with a genuine appreciation ofthe practice and challenges of clinical rehabilitation. This program is centered in the Department of Biomedical Engineering at Case Western Reserve University, but also includes the strong participation of several of our local medical centers. Our program is focused exclusively on predoctoral training and we have trained ~25 students since 1999. We are requesting funding for a total of 8 training positions per year for five years, which would maintain our current level of support. Trainees are typically funded by the program for two years each, so we expect to train a total of 20 BME Ph.D. students over the proposed five years. The specific objectives of our training program arei (1) Prepare our trainees for productive careers in rehabilitation and neural engineering;(2) Provide a rigorous engineering education that forms the basis for future innovation;(3) Provide specific expertise in the development and application of neural stimulation for overcoming neurological disorders;(4) Provide specific expertise in modeling and simulation (musculoskeletal and/or neural);(5) Provide an extensive, hands-on clinical experience that prepares each trainee for a translational career;and (6) Provide real-world professional development training to enhance post-graduation success.

Public Health Relevance

Disability due to neurological disorders is a major medical challenge that can often mitigated by application of electrical stimulation to specific neural structures. Research and commercial applications related to neural stimulation are growing almost exponentially, leading to a real need for highly qualified, Ph.D.-level engineers who have the technical and clinical backgrounds provided by this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB004314-14
Application #
8325964
Study Section
Special Emphasis Panel (ZEB1-OSR-E (M1))
Program Officer
Erim, Zeynep
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
14
Fiscal Year
2012
Total Cost
$266,690
Indirect Cost
$14,457
Name
Case Western Reserve University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Ravikumar, Madhumitha; Sunil, Smrithi; Black, James et al. (2014) The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes. Biomaterials 35:8049-64
Potter-Baker, Kelsey A; Nguyen, Jessica K; Kovach, Kyle M et al. (2014) Development of Superoxide Dismutase Mimetic Surfaces to Reduce Accumulation of Reactive Oxygen Species for Neural Interfacing Applications. J Mater Chem B Mater Biol Med 2:2248-2258
Peterson, E J; Tyler, D J (2014) Motor neuron activation in peripheral nerves using infrared neural stimulation. J Neural Eng 11:016001
Ravikumar, Madhumitha; Hageman, Daniel J; Tomaszewski, William H et al. (2014) The Effect of Residual Endotoxin Contamination on the Neuroinflammatory Response to Sterilized Intracortical Microelectrodes. J Mater Chem B Mater Biol Med 2:2517-2529
Nguyen, Jessica K; Park, Daniel J; Skousen, John L et al. (2014) Mechanically-compliant intracortical implants reduce the neuroinflammatory response. J Neural Eng 11:056014
Potter-Baker, Kelsey A; Ravikumar, Madhumitha; Burke, Alan A et al. (2014) A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models. Biomaterials 35:5637-46
Fisher, Lee E; Tyler, Dustin J; Triolo, Ronald J (2013) Optimization of selective stimulation parameters for multi-contact electrodes. J Neuroeng Rehabil 10:25
Makowski, Nathaniel; Knutson, Jayme; Chae, John et al. (2013) Interaction of poststroke voluntary effort and functional neuromuscular electrical stimulation. J Rehabil Res Dev 50:85-98
McCoin, Jaime L; Bhadra, Narendra; Gustafson, Kenneth J (2013) Electrical stimulation of sacral dermatomes can suppress aberrant urethral reflexes in felines with chronic spinal cord injury. Neurourol Urodyn 32:92-7
Foldes, Stephen T; Taylor, Dawn M (2013) Speaking and cognitive distractions during EEG-based brain control of a virtual neuroprosthesis-arm. J Neuroeng Rehabil 10:116

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