A training program entitled Translational Research in Biomaterials (TRB) is proposed whereby women and men will learn how to """"""""translate"""""""" their research ideas from the laboratory to the clinic. The mission of our program is to train Ph.D. students as interdisciplinary and translational research scientists who have: 1) a fundamental and quantitative understanding of materials, polymer chemistry, surface science, host-tissue response, and molecular and cellular biology;2) exposure to engineering technologies and characterization techniques;3) research experience in interdisciplinary programs that promote discussion and scientific inquiry in areas outside of the student's """"""""comfort zone"""""""";and 4) training in societal impacts of new technology, public policy, ethics, clinical trials, and basic business. The capstone of the TRB program is the education curriculum that combines interdisciplinary research, quantitative science and engineering courses, translational-based courses in clinical trials and business, laboratory modules, a student-organized journal club, medical grand rounds, surgical theater, training in professional ethics, and industrial internships to train students. These skills are essential in future careers as graduates join teams that combine diverse backgrounds to meet a common goal in research, development, and ultimately commercialization. Impact on public health: Training young scientists and engineers in biomaterials will facilitate the implementation of biomaterial-based technologies, including tissue-engineering approaches, to the clinic. Specifically, this curriculum gives students the creative and analytical skills they will need to develop new and differentiated products in areas including orthopedics, ophthalmology, and cardiology.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZEB1-OSR-E (O1))
Program Officer
Baird, Richard A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Arts and Sciences
United States
Zip Code
Li, David; Jacobsen, Matthew M; Gyune Rim, Nae et al. (2017) Introducing biomimetic shear and ion gradients to microfluidic spinning improves silk fiber strength. Biofabrication 9:025025
Cooper, B G; Lawson, T B; Snyder, B D et al. (2017) Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support. Osteoarthritis Cartilage 25:1143-1149
Tevis, Kristie M; Cecchi, Ryan J; Colson, Yolonda L et al. (2017) Mimicking the tumor microenvironment to regulate macrophage phenotype and assessing chemotherapeutic efficacy in embedded cancer cell/macrophage spheroid models. Acta Biomater 50:271-279
Reynolds, Daniel S; Tevis, Kristie M; Blessing, William A et al. (2017) Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment. Sci Rep 7:10382
Jacobsen, Matthew M; Li, David; Gyune Rim, Nae et al. (2017) Silk-fibronectin protein alloy fibres support cell adhesion and viability as a high strength, matrix fibre analogue. Sci Rep 7:45653
Colby, Aaron H; Oberlies, Nicholas H; Pearce, Cedric J et al. (2017) Nanoparticle drug-delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle. Wiley Interdiscip Rev Nanomed Nanobiotechnol 9:
Wang, Julia; Kaplan, Jonah A; Colson, Yolonda L et al. (2017) Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release. Adv Drug Deliv Rev 108:68-82
Colby, Aaron H; Berry, Samantha M; Moran, Ann M et al. (2017) Highly Specific and Sensitive Fluorescent Nanoprobes for Image-Guided Resection of Sub-Millimeter Peritoneal Tumors. ACS Nano 11:1466-1477
Falde, E J; Wang, J; Grinstaff, M W (2017) Surface Tension Sensor Meshes for Rapid Alcohol Quantification. RSC Adv 7:49795-49798
Konieczynska, Marlena D; Villa-Camacho, Juan C; Ghobril, Cynthia et al. (2016) On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction. Angew Chem Int Ed Engl 55:9984-7

Showing the most recent 10 out of 25 publications