The Interdisciplinary Biomedical Imaging Training Program will prepare predoctoral trainees to become leaders in organism-level, biomedical imaging research. Multi-disciplinary teams of engineers, physicists, biologists, and clinicians are required to advance biomedical imaging, especially with the advent of in vivo cellular and molecular imaging. We will create the next generation of interdisciplinary biomedical imaging scientists and engineers who will contribute to and lead such teams. Our training program will build upon continuing, significant institutional, state, federal, and commercial investment in faculty and imaging infrastructure. A training grant award will place students squarely in the center of on-going interdisciplinary/multidisciplinary research programs. Trainees will use imaging facilities in the Case Center for Imaging Research which includes state-of- the-art clinical and small animal imaging systems, along with labs of mentoring faculty. Predoctoral trainees will be from the highly-rated departments of Biomedical Engineering and Physics, both of which have a long history of training in biomedical imaging. Trainees will conduct research projects combining enabling technologies in imaging with biomedical research. Each trainee will have two or more mentors representing both imaging technology and biological/clinical applications of imaging. Our educational program includes a portfolio of imaging courses, including ones focusing on imaging physics, image analysis, and reconstruction, as well as Cellular and Molecular Imaging and Nanomedicine (Nanosized Therapeutics and Imaging Agents), a new course specially designed for interdisciplinary training in nanoparticle theranostics. We will promote a culture of inter- disciplinary research in a series of diverse activities during a designated Imaging Hour. Training funds are mostly used to recruit first year graduate students, a significant need at our institution. Our T32 has enabled us to increase recruitment of women and under-represented minorities. In general, it has helped make graduate students cost effective as compared to post docs and ensured training of domestic PhD's in this area of critical need. In less than four years, our T32 program has already successfully trained four graduates, all with exemplary training records and with a trajectory towards success. Other trainees are moving through the program focusing on exciting interdisciplinary imaging research and with excellent research productivity.

Public Health Relevance

Biomedical imaging enables early detection, assessment of therapy, and minimally-invasive treatment of disease. Especially with the advent of cellular and molecular imaging, biomedical imaging research requires persons with strong interdisciplinary training.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB007509-08
Application #
8723651
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Baird, Richard A
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biomedical Engineering
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zhou, Haoyan; Goss, Monika; Hernandez, Christopher et al. (2016) Validation of Ultrasound Elastography Imaging for Nondestructive Characterization of Stiffer Biomaterials. Ann Biomed Eng 44:1515-23
Wen, Amy M; Lee, Karin L; Cao, Pengfei et al. (2016) Utilizing Viral Nanoparticle/Dendron Hybrid Conjugates in Photodynamic Therapy for Dual Delivery to Macrophages and Cancer Cells. Bioconjug Chem 27:1227-35
Askew, David; Su, Charles A; Barkauskas, Deborah S et al. (2016) Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response. J Immunol 196:3653-64
Chariou, Paul L; Lee, Karin L; Pokorski, Jonathan K et al. (2016) Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio. J Phys Chem B 120:6120-9
Deshmane, Anagha; Blaimer, Martin; Breuer, Felix et al. (2016) Self-calibrated trajectory estimation and signal correction method for robust radial imaging using GRAPPA operator gridding. Magn Reson Med 75:883-96
Hamilton, Jesse I; Jiang, Yun; Chen, Yong et al. (2016) MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density. Magn Reson Med :
Hernandez, Christopher; Gawlik, Natalia; Goss, Monika et al. (2016) Macroporous acrylamide phantoms improve prediction of in vivo performance of in situ forming implants. J Control Release 243:225-231
Peiris, Pubudu M; Deb, Partha; Doolittle, Elizabeth et al. (2015) Vascular Targeting of a Gold Nanoparticle to Breast Cancer Metastasis. J Pharm Sci 104:2600-10
Doolittle, Elizabeth; Peiris, Pubudu M; Doron, Gilad et al. (2015) Spatiotemporal Targeting of a Dual-Ligand Nanoparticle to Cancer Metastasis. ACS Nano 9:8012-21
Bauer, Lisa M; Situ, Shu F; Griswold, Mark A et al. (2015) Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions. J Phys Chem Lett 6:2509-17

Showing the most recent 10 out of 91 publications