Application is made for continued funding of a long-standing programassociated withthe Center in Molecular Toxicology at Vanderbilt University. Funds are requested to support eight predoctoral trainees (Ph.D. candidates) and six postdoctoral trainees (those having a Ph.D., M.D., D.V.M., etc.). This interdisciplinary program emphasizes molecular aspects of toxicology related to environmental health. The faculty is drawn from individuals with appointments in Biochemistry, Biological Sciences, Chemistry, Medicine, Pathology, Pediatrics, and Pharmacology, all of whom train postdoctoral fellows. Graduate students in the program obtain degrees through Biochemistry, Biological Sciences, Chemistry, Pathology, or Pharmacology. Considerable emphasis is placed upon research rotations, the thesis research itself, and participation in seminars, journal clubs, and joint research meetings. There is also much opportunity for learning operation and application of instrumental systems in research. Graduate students are recruited to the Departments of Biological Sciences and Chemistry through departmental mechanisms, with assistance from the Center in Molecular Toxicology. In the other three (biomedical) departments, graduate students are initially recruited into either the Interdisciplinary Graduate Program or the Chemical and Physical Biology Program, where they spend the first 9 months in a relatively common core curriculum and do four laboratory rotations. Graduate students are recruited into Toxicology from these first year pools (theinitial year is supported by the institution). Both predoctoral and postdoctoral trainees are selected by the Center's Steering Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes twenty-two faculty who are all Center Investigators. Major research areas in the Center include oxidative damage, DMA damage and genetic instability, maintenance of genomic integrity, enzymatic biotransformation and reactions of electrophiles, and neurotoxicology. Molecular toxicology is recognized as a strong program, and the institution has continued its commitment to making Vanderbilt a leading center for training in this area.

Public Health Relevance

This interdisciplinary program has a long-standing and successful history of training individuals in the molecular aspects of environmental toxicology. Many former trainees of the program have gone on to productive careers in academia, industry, and government institutes. Pre- and postdoctoraltrainees receive a strong background in basic science with opportunities to participate in clinical and translational research. The ultimate goal of this program is to train future scientists in areas relevant to improving human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007028-38
Application #
8296312
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1975-07-10
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
38
Fiscal Year
2012
Total Cost
$572,806
Indirect Cost
$40,467
Name
Vanderbilt University Medical Center
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Brinkhaus, Sigrid Grosse; Bornhorst, Julia; Chakraborty, Sudipta et al. (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6:617-21
Bornhorst, Julia; Chakraborty, Sudipta; Meyer, Sören et al. (2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of ?-synuclein in C. elegans. Metallomics 6:476-90
Mason, Aaron C; Rambo, Robert P; Greer, Briana et al. (2014) A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proc Natl Acad Sci U S A 111:7618-23
Carroll, Clinton; Bansbach, Carol E; Zhao, Runxiang et al. (2014) Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity. Nucleic Acids Res 42:918-25
Galligan, James J; Rose, Kristie L; Beavers, William N et al. (2014) Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics. J Am Chem Soc 136:11864-6
Yoshimoto, Francis K; Guengerich, F Peter (2014) Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. J Am Chem Soc 136:15016-25
Lamberson, Connor R; Xu, Libin; Muchalski, Hubert et al. (2014) Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. J Am Chem Soc 136:838-41
Caito, Samuel; Zeng, Heng; Aschner, Judy L et al. (2014) Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS. PLoS One 9:e98161
Zhao, Linlin; Pence, Matthew G; Eoff, Robert L et al. (2014) Elucidation of kinetic mechanisms of human translesion DNA polymerase ? using tryptophan mutants. FEBS J 281:4394-410
Frank, Andreas O; Vangamudi, Bhavatarini; Feldkamp, Michael D et al. (2014) Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem 57:2455-61

Showing the most recent 10 out of 178 publications