The applicants are applying for support for years 36 to 40 of the Environmental Pathology/Toxicology (EP/T) Training Program at the University of Washington (UW). This training program has been continuously funded by the NIEHS since 1978. The long-term goal of the program remains mentoring pre- and postdoctoral trainees to become successful independent scientists who are well equipped to respond to the environmental health research needs of the US in the coming generations. This long-established program has been highly successful in this endeavor, and the current application incorporates the themes and goals of the 2012 NIEHS Strategic Plan. The Training Program is a 30-year-long collaboration between the Department of Pathology in the School of Medicine and the Department of Environmental and Occupational Health Sciences (DEOHS) in the School of Public Health. In the previous cycle, the applicants added the outstanding Department of Genome Sciences in the School of Medicine to enhance the training experience and to stay current with exciting advances in gene-environment approaches to improving environmental health research. The EP/T Training Program is directed by Dr. Thomas Montine (Program Director), Dr. Elaine Faustman (Associate Director), and Dr. David Eaton, (Associate Director). The EP/T Training Program (i) embraces virtually all NIEHS-supported investigators at UW, including the addition this cycle of several experts in exposure science, (ii) is closely linked wih NIEHS- supported centers at UW focused on ecogenetics, toxicogenomics, and risk assessment, among others, (iii) and is highly integrated with a wide array of well-funded, complementary research centers and projects. Given the excellent track record of training, as well as the outstanding and growing opportunities at UW, the applicants are requesting renewal of their training grant, so that they can continue to train future leaders in environmental health science.

Public Health Relevance

Environmental exposure to chemical and physical agents continues to be a major public health problem in the United States and worldwide, and the need for well-trained scientists to conduct research on such pressing health challenges remains compelling. The applicants believe that training environmental health scientists to be future experts in fundamental research in pathology, toxicology, exposure research, and translational research with a focus on health disparities and global health is a tangible and effective way to contribute to this national and international need within the vision set by of the 2012 NIEHS Strategic Plan.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZES1-JAB-J (T2))
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Shreffler, Carol K
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University of Washington
Schools of Medicine
United States
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Harris, Sean; Shubin, Sara Pacheco; Wegner, Susanna et al. (2016) The presence of macrophages and inflammatory responses in an in vitro testicular co-culture model of male reproductive development enhance relevance to in vivo conditions. Toxicol In Vitro 36:210-5
Meador, James P; Yeh, Andrew; Young, Graham et al. (2016) Contaminants of emerging concern in a large temperate estuary. Environ Pollut 213:254-67
Wang, Lu; Espinoza, Herbert M; MacDonald, James W et al. (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57
Sunshine, Anna B; Ong, Giang T; Nickerson, Daniel P et al. (2016) Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae. Aging Cell 15:317-24
Cook, Travis J; Hoekstra, Jake G; Eaton, David L et al. (2016) Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients. Brain Pathol 26:75-81
Manichaikul, Ani; Wang, Xin-Qun; Zhao, Wei et al. (2016) Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis. J Lipid Res 57:433-42
Vandeven, Natalie A; Nghiem, Paul (2016) Merkel Cell Carcinoma: An Unusually Immunogenic Cancer Proves Ripe for Immune Therapy. J Oncol Pract 12:649-50
Cole, Toby B; Coburn, Jacki; Dao, Khoi et al. (2016) Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 374:1-9
Harris, Sean; Wegner, Susanna; Hong, Sung Woo et al. (2016) Phthalate metabolism and kinetics in an in vitro model of testis development. Toxicol In Vitro 32:123-31
Walker, Ashley E; Morgan, R Garrett; Ives, Stephen J et al. (2016) Age-related arterial telomere uncapping and senescence is greater in women compared with men. Exp Gerontol 73:65-71

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