This NIEHS training grant has been active for 30 years and has supported 102 pre-doctorates and 15 post-doctorates. These trainees have gone on to successful careers in toxicology in academia, industry, government and the private sector. This training program has been extensively revised to be in accord with the NIEHS mission and the new NIEHS T32 guidelines. The objective of this training program entitled, Molecular Pathways to Pathogenesis in Toxicology, is to provide trainees with the skills and knowledge necessary to investigate and elucidate how environmental toxicants/cellular stressors contribute to toxicity and influence disease outcomes. The broad overarching research theme is to understand how toxicants/stressors perturb cellular signaling pathways and deregulates gene expression, and how this peturbation/deregulation contributes to toxicity and disease outcomes. Specific environmental-associated human diseases/conditions such as asthma, lung fibrosis, reproductive/endocrine abnormalities, developmental abnormalities and cancer as well as ROS- related toxicity will be the focal molecular/cellular research areas. Examples of types of environmental agents that will be investigated include environmental carcinogens, pesticides, particulates, metals, endocrine disrupters and nanoparticles. There are eighteen faculty from 3 colleges and 6 departments that are participating in this interdisciplinary training program. Importantly, this training grant is administered through the Department of Environmental and Molecular Toxicology which provides a structured cohesive environment for trainees. Pre-doctoral trainees acquire a solid background by completing coursework in toxicology, molecular biology, pharmacology, statistics, and pathology. Pre/postdoctoral trainees receive training in ethics, grant writing and oral communication skills. Pre/postdoctoral trainees participate in a weekly seminar program both as members of the audience and as presenters. Each semester a former trainee is invited back to the Department to present a seminar and to share their career experiences with current trainees. A plan is in place with the College of Veterinary Medicine that will enhance the recruitment of veterinarians (DVMs) interested in human health to postdoctoral positions on this grant. Support for 6 pre-doctoral and 3 postdoctoral trainee positions is requested. Relevance: The proposed research training involving toxicants, signaling pathways/cascades, toxicity and disease will aid society to: 1) assess the impact of environmental factors on human health and disease, 2) understand the mechanisms through which toxicants produce their adverse effects, 3) identify potential human health hazards and prevent diseases and unnecessary exposure to toxic agents.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007046-35
Application #
8692764
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
35
Fiscal Year
2014
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Public Health & Prev Medicine
Type
Earth Sciences/Resources
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Bogdan, Alexander R; Miyazawa, Masaki; Hashimoto, Kazunori et al. (2016) Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Trends Biochem Sci 41:274-86
He, X; Zhou, S; St Armour, G E et al. (2016) Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. Genes Brain Behav 15:280-90
Dandley, Erinn C; Taylor, Alexia J; Duke, Katherine S et al. (2016) Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure. Part Fibre Toxicol 13:29
Wilson, Briana R; Bogdan, Alexander R; Miyazawa, Masaki et al. (2016) Siderophores in Iron Metabolism: From Mechanism to Therapy Potential. Trends Mol Med 22:1077-1090
Zhou, Shanshan; Morozova, Tatiana V; Hussain, Yasmeen N et al. (2016) The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Environ Health Perspect 124:1062-70
Kollitz, Erin M; Zhang, Guozhu; Hawkins, Mary Beth et al. (2015) Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates. PLoS One 10:e0122853
Adoteye, Kaska; Banks, H T; Cross, Karissa et al. (2015) Statistical validation of structured population models for Daphnia magna. Math Biosci 266:73-84
Shipkowski, Kelly A; Taylor, Alexia J; Thompson, Elizabeth A et al. (2015) An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1. PLoS One 10:e0128888
Hall, J R; Messenger, Z J; Tam, H W et al. (2015) Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death Dis 6:e1700
Hilton, Gina M; Taylor, Alexia J; McClure, Christina D et al. (2015) Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS. Toxicology 329:80-7

Showing the most recent 10 out of 100 publications