The objective of this program is to train future leaders in environmental health sciences (EHS) by providing transdisciplinary research training that bridges environmental mechanistic toxicology and environmental molecular epidemiology with applications to human disease prevention. The program is based on the premise that modern EHS scientists specializing in toxicology or epidemiology require training in multiple disciplinary approaches in order to conduct translational research, including the evolving technologies of genomics, proteomics and bioinformatics. The proposed program is an evolution of the investigators'current program which has provided training in mechanistic toxicology for 25 years. The changes allow them to capitalize on a recent expansion in faculty conducting cutting-edge transdisciplinary research. Pre-doctoral trainees will specialize in environmental epidemiology or mechanistic toxicology, and will take a foundation course and an advanced course in the non-specialization area (i.e., epidemiology trainees take toxicology courses and visa versa). In addition, there is a common core curriculum of translational research and bioinformatics courses. To accommodate the program's expansion, the investigators request 8 pre-doctoral and 4 postdoctoral positions (at levels 0,1 and 2) in this submission, increased from 6 pre-doctoral and 2 postdoctoral positions in the last cycle. The expected duration of trainee support on this training grant is two years, though the expected total duration of pre-doctoral training is 4-5 years. Postdoctoral trainees will be encouraged to submit an F32 Individual NRSA Postdoctoral Fellowship application in their first year of training. Qualified applicants must demonstrate motivation for careers in EHS mechanistic toxicology or mechanistically-oriented epidemiology research. Pre-doctoral trainees must have a baccalaureate degree with relevant scientific coursework preparation and will be enrolled in a Ph.D. program in the Department of EHS, which has a distinguished history of graduate training in toxicology. Postdoctoral fellows must have the PhD, MD, DVM, or other appropriate doctoral degree. Although the investigators expect that most postdoctoral trainees will hold Ph.D. degrees, they also anticipate offering 1-2 postdoctoral fellowships to candidates holding clinical degrees. Relevance: This program will provide transdisciplinary training of environmental health scientists in emerging research approaches and technologies to increase the tempo of research findings that promote human disease prevention from environmental exposures.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Public Health & Prev Medicine
Schools of Public Health
Ann Arbor
United States
Zip Code
Marchlewicz, Elizabeth H; Dolinoy, Dana C; Tang, Lu et al. (2016) Lipid metabolism is associated with developmental epigenetic programming. Sci Rep 6:34857
Russ, K A; Elvati, P; Parsonage, T L et al. (2016) C60 fullerene localization and membrane interactions in RAW 264.7 immortalized mouse macrophages. Nanoscale 8:4134-44
Guilarte, Tomás R; Loth, Meredith K; Guariglia, Sara R (2016) TSPO Finds NOX2 in Microglia for Redox Homeostasis. Trends Pharmacol Sci :
Aker, Amira M; Watkins, Deborah J; Johns, Lauren E et al. (2016) Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environ Res 151:30-37
Parajuli, Rajendra Prasad; Goodrich, Jaclyn M; Chou, Hwai-Nan et al. (2016) Genetic polymorphisms are associated with hair, blood, and urine mercury levels in the American Dental Association (ADA) study participants. Environ Res 149:247-58
Bergin, Ingrid L; Wilding, Laura A; Morishita, Masako et al. (2016) Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model. Nanotoxicology 10:352-60
Magnuson, Brian; Bedi, Karan; Ljungman, Mats (2016) Genome stability versus transcript diversity. DNA Repair (Amst) 44:81-6
Huang, Siying; Hu, Howard; Sánchez, Brisa N et al. (2016) Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children. Environ Health Perspect 124:868-74
Cantonwine, David E; Ferguson, Kelly K; Mukherjee, Bhramar et al. (2016) Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure. PLoS One 11:e0146532
Carter, Eric L; Gupta, Nirupama; Ragsdale, Stephen W (2016) High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor. J Biol Chem 291:2196-222

Showing the most recent 10 out of 180 publications