The objective of this program is to train future leaders in environmental health sciences (EHS) by providing transdisciplinary research training that bridges environmental mechanistic toxicology and environmental molecular epidemiology with applications to human disease prevention. The program is based on the premise that modern EHS scientists specializing in toxicology or epidemiology require training in multiple disciplinary approaches in order to conduct translational research, including the evolving technologies of genomics, proteomics and bioinformatics. The proposed program is an evolution of the investigators'current program which has provided training in mechanistic toxicology for 25 years. The changes allow them to capitalize on a recent expansion in faculty conducting cutting-edge transdisciplinary research. Pre-doctoral trainees will specialize in environmental epidemiology or mechanistic toxicology, and will take a foundation course and an advanced course in the non-specialization area (i.e., epidemiology trainees take toxicology courses and visa versa). In addition, there is a common core curriculum of translational research and bioinformatics courses. To accommodate the program's expansion, the investigators request 8 pre-doctoral and 4 postdoctoral positions (at levels 0,1 and 2) in this submission, increased from 6 pre-doctoral and 2 postdoctoral positions in the last cycle. The expected duration of trainee support on this training grant is two years, though the expected total duration of pre-doctoral training is 4-5 years. Postdoctoral trainees will be encouraged to submit an F32 Individual NRSA Postdoctoral Fellowship application in their first year of training. Qualified applicants must demonstrate motivation for careers in EHS mechanistic toxicology or mechanistically-oriented epidemiology research. Pre-doctoral trainees must have a baccalaureate degree with relevant scientific coursework preparation and will be enrolled in a Ph.D. program in the Department of EHS, which has a distinguished history of graduate training in toxicology. Postdoctoral fellows must have the PhD, MD, DVM, or other appropriate doctoral degree. Although the investigators expect that most postdoctoral trainees will hold Ph.D. degrees, they also anticipate offering 1-2 postdoctoral fellowships to candidates holding clinical degrees. Relevance: This program will provide transdisciplinary training of environmental health scientists in emerging research approaches and technologies to increase the tempo of research findings that promote human disease prevention from environmental exposures.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Public Health & Prev Medicine
Schools of Public Health
Ann Arbor
United States
Zip Code
Watkins, Deborah J; Ferguson, Kelly K; Anzalota Del Toro, Liza V et al. (2015) Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. Int J Hyg Environ Health 218:212-9
Darr, Owen A; Colacino, Justin A; Tang, Alice L et al. (2015) Epigenetic alterations in metastatic cutaneous carcinoma. Head Neck 37:994-1001
Boldenow, Erica; Hogan, Kelly A; Chames, Mark C et al. (2015) Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am J Reprod Immunol 73:263-72
Nahar, Muna S; Liao, Chunyang; Kannan, Kurunthachalam et al. (2015) In utero bisphenol A concentration, metabolism, and global DNA methylation across matched placenta, kidney, and liver in the human fetus. Chemosphere 124:54-60
Weinhouse, Caren; Anderson, Olivia S; Bergin, Ingrid L et al. (2014) Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A. Environ Health Perspect 122:485-91
Kim, Jung H; Sartor, Maureen A; Rozek, Laura S et al. (2014) Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome. BMC Genomics 15:30
Basu, Niladri; Tutino, Rebecca; Zhang, Zhenzhen et al. (2014) Mercury levels in pregnant women, children, and seafood from Mexico City. Environ Res 135:63-9
Faulk, Christopher; Barks, Amanda; Sánchez, Brisa N et al. (2014) Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course. PLoS One 9:e104273
Watkins, Deborah J; Téllez-Rojo, Martha Maria; Ferguson, Kelly K et al. (2014) In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation. Environ Res 134:233-41
Park, Hae-Ryung; Kamau, Patricia W; Korte, Cassandra et al. (2014) Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reprod Toxicol 50:154-62

Showing the most recent 10 out of 85 publications