The objective of this program is to train future leaders in environmental health sciences (EHS) by providing transdisciplinary research training that bridges environmental mechanistic toxicology and environmental molecular epidemiology with applications to human disease prevention. The program is based on the premise that modern EHS scientists specializing in toxicology or epidemiology require training in multiple disciplinary approaches in order to conduct translational research, including the evolving technologies of genomics, proteomics and bioinformatics. The proposed program is an evolution of the investigators'current program which has provided training in mechanistic toxicology for 25 years. The changes allow them to capitalize on a recent expansion in faculty conducting cutting-edge transdisciplinary research. Pre-doctoral trainees will specialize in environmental epidemiology or mechanistic toxicology, and will take a foundation course and an advanced course in the non-specialization area (i.e., epidemiology trainees take toxicology courses and visa versa). In addition, there is a common core curriculum of translational research and bioinformatics courses. To accommodate the program's expansion, the investigators request 8 pre-doctoral and 4 postdoctoral positions (at levels 0,1 and 2) in this submission, increased from 6 pre-doctoral and 2 postdoctoral positions in the last cycle. The expected duration of trainee support on this training grant is two years, though the expected total duration of pre-doctoral training is 4-5 years. Postdoctoral trainees will be encouraged to submit an F32 Individual NRSA Postdoctoral Fellowship application in their first year of training. Qualified applicants must demonstrate motivation for careers in EHS mechanistic toxicology or mechanistically-oriented epidemiology research. Pre-doctoral trainees must have a baccalaureate degree with relevant scientific coursework preparation and will be enrolled in a Ph.D. program in the Department of EHS, which has a distinguished history of graduate training in toxicology. Postdoctoral fellows must have the PhD, MD, DVM, or other appropriate doctoral degree. Although the investigators expect that most postdoctoral trainees will hold Ph.D. degrees, they also anticipate offering 1-2 postdoctoral fellowships to candidates holding clinical degrees. Relevance: This program will provide transdisciplinary training of environmental health scientists in emerging research approaches and technologies to increase the tempo of research findings that promote human disease prevention from environmental exposures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007062-30
Application #
8501452
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1979-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
30
Fiscal Year
2013
Total Cost
$430,271
Indirect Cost
$24,761
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cathey, Amber; Ferguson, Kelly K; McElrath, Thomas F et al. (2018) Distribution and predictors of urinary polycyclic aromatic hydrocarbon metabolites in two pregnancy cohort studies. Environ Pollut 232:556-562
Kochmanski, Joseph J; Marchlewicz, Elizabeth H; Cavalcante, Raymond G et al. (2018) Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood. Environ Health Perspect 126:077006
Colacino, Justin A; Azizi, Ebrahim; Brooks, Michael D et al. (2018) Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling. Stem Cell Reports 10:1596-1609
Elkin, Elana R; Harris, Sean M; Loch-Caruso, Rita (2018) Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicol Appl Pharmacol 338:30-42
Carlson, Krystin; Schacht, Jochen; Neitzel, Richard L (2018) Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse. J Toxicol Environ Health A 81:1041-1057
Aker, Amira M; Johns, Lauren; McElrath, Thomas F et al. (2018) Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environ Int 113:341-349
Jacobs, Haydee M; Sant, Karilyn E; Basnet, Aviraj et al. (2018) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere 195:498-507
Neier, K; Cheatham, D; Bedrosian, L D et al. (2018) Perinatal exposures to phthalates and phthalate mixtures result in sex-specific effects on body weight, organ weights and intracisternal A-particle (IAP) DNA methylation in weanling mice. J Dev Orig Health Dis :1-12
Kochmanski, Joseph; Goodrich, Jaclyn M; Peterson, Karen E et al. (2018) Neonatal bloodspot DNA methylation patterns are associated with childhood weight status in the Healthy Families Project. Pediatr Res :
Koman, Patricia D; Hogan, Kelly A; Sampson, Natalie et al. (2018) Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining ""At-Risk"" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy. World Med Health Policy 10:7-54

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