During the past 30 years, over 300 students have received instruction in the toxicological sciences Toxicology Training from this program. Among our trainees were 18 who received Master's degrees, 102 who received Ph.D. degrees, 139 postdoctoral fellow, and 55 medical students (short-term trainees). Contained in this proposal is a request for five additional years of funding for this Toxicology Training Program (TTP). In support of this, details are provided on recruiting and retaining students, including minority fellows. Also included are changes in the program over the past decade including modifications in and modernization of the curriculum. Thanks to continued institutional support, the past decade has witnessed changes in the TTP to modernize the training, to improve recruitment, to streamline and update courses, to increase the number of participating faculty, and to enhance student exposure to outside leaders and opportunities in the field, and the recruitment of 18 faculty in the Department of Pharmacology, Toxicology, and Therapeutics (DPTT), and with the plan to hire another seven faculty over the next five years. In addition, faculty from other basic science departments have been added to the program as well as a number of clinical researchers and the development of a Liver Center to increase the translational aspects of the training program. Therefore, the program is positioned to maintain its international reputation as a Center of Excellence for training in toxicology.

Public Health Relevance

Chemicals are present in the air we breathe, as well as in the food and water that we drink. Research is needed to understand how these chemicals produce their toxic effects, so we can protect and treat these adverse effects. This program will train the next generation of toxicologists to perform these essential roles.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007079-33
Application #
8501454
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1979-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$322,666
Indirect Cost
$22,090
Name
University of Kansas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Bu, Pengli; Yagi, Shintaro; Shiota, Kunio et al. (2017) Origin of a rapidly evolving homeostatic control system programming testis function. J Endocrinol 234:217-232
Weemhoff, James L; Woolbright, Benjamin L; Jenkins, Rosalind E et al. (2017) Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis. Liver Int 37:377-384
McCracken, Jennifer M; Chalise, Prabhakar; Briley, Shawn M et al. (2017) C57BL/6 Substrains Exhibit Different Responses to Acute Carbon Tetrachloride Exposure: Implications for Work Involving Transgenic Mice. Gene Expr 17:187-205
McGreal, Steven R; Rumi, Karim; Soares, Michael J et al. (2017) Disruption of Estrogen Receptor Alpha in Rats Results in Faster Initiation of Compensatory Regeneration Despite Higher Liver Injury After Carbon Tetrachloride Treatment. Int J Toxicol 36:199-206
Bhushan, Bharat; Poudel, Samikshya; Manley Jr, Michael W et al. (2017) Inhibition of Glycogen Synthase Kinase 3 Accelerated Liver Regeneration after Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol 187:543-552
Woolbright, Benjamin L; Williams, C David; Ni, Hongmin et al. (2017) Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis. Toxicon 125:99-109
Woolbright, Benjamin L; Jaeschke, Hartmut (2017) Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. J Hepatol 66:836-848
Chavan, Hemantkumar; Christudoss, Pamela; Mickey, Kristen et al. (2017) Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response. Oxid Med Cell Longev 2017:9251303
Woolbright, Benjamin L; Ding, Wen-Xing; Jaeschke, Hartmut (2017) Caspase inhibitors for the treatment of liver disease: friend or foe? Expert Rev Gastroenterol Hepatol 11:397-399
Du, Kuo; Ramachandran, Anup; McGill, Mitchell R et al. (2017) Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol 108:339-350

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