During the past 30 years, over 300 students have received instruction in the toxicological sciences Toxicology Training from this program. Among our trainees were 18 who received Master's degrees, 102 who received Ph.D. degrees, 139 postdoctoral fellow, and 55 medical students (short-term trainees). Contained in this proposal is a request for five additional years of funding for this Toxicology Training Program (TTP). In support of this, details are provided on recruiting and retaining students, including minority fellows. Also included are changes in the program over the past decade including modifications in and modernization of the curriculum. Thanks to continued institutional support, the past decade has witnessed changes in the TTP to modernize the training, to improve recruitment, to streamline and update courses, to increase the number of participating faculty, and to enhance student exposure to outside leaders and opportunities in the field, and the recruitment of 18 faculty in the Department of Pharmacology, Toxicology, and Therapeutics (DPTT), and with the plan to hire another seven faculty over the next five years. In addition, faculty from other basic science departments have been added to the program as well as a number of clinical researchers and the development of a Liver Center to increase the translational aspects of the training program. Therefore, the program is positioned to maintain its international reputation as a Center of Excellence for training in toxicology.

Public Health Relevance

Chemicals are present in the air we breathe, as well as in the food and water that we drink. Research is needed to understand how these chemicals produce their toxic effects, so we can protect and treat these adverse effects. This program will train the next generation of toxicologists to perform these essential roles.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
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University of Kansas
Schools of Medicine
Kansas City
United States
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McGill, Mitchell R; Kennon-McGill, Stefanie; Durham, Dianne et al. (2016) Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study. Toxicol Mech Methods 26:104-11
Deshpande, Krutika T; Liu, Shinlan; McCracken, Jennifer M et al. (2016) Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice. Biomolecules 6:5
Li, Yuan; McGreal, Steven; Zhao, Jean et al. (2016) A cell-based quantitative high-throughput image screening identified novel autophagy modulators. Pharmacol Res 110:35-49
Woolbright, Benjamin L; Jaeschke, Hartmut (2016) Noncoding RNAs as therapeutics for acetaminophen-induced liver injury. Stem Cell Investig 3:54
Ni, Hong-Min; McGill, Mitchell R; Chao, Xiaojuan et al. (2016) Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. J Hepatol 65:354-62
Magee, Nancy; Zou, An; Zhang, Yuxia (2016) Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells. Biomed Res Int 2016:5170402
Woolbright, Benjamin L; McGill, Mitchell R; Yan, Huimin et al. (2016) Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. Basic Clin Pharmacol Toxicol 118:160-7
McCracken, Jennifer M; Jiang, Lu; Deshpande, Krutika T et al. (2016) Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. Fibrogenesis Tissue Repair 9:4
Duan, Luqi; Davis, John S; Woolbright, Benjamin L et al. (2016) Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. Food Chem Toxicol 98:107-118
Briley, Shawn M; Jasti, Susmita; McCracken, Jennifer M et al. (2016) Reproductive age-associated fibrosis in the stroma of the mammalian ovary. Reproduction 152:245-60

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