The Toxicology Graduate Program at the University of Arizona has a long-standing reputation for excellence in training Ph.D. scientist. Many of our graduates are now leaders in academia, industry, and government. Current trainees are now selected through a University-wide competition. The graduate program has evolved from a systems-based toxicology experience to training students to apply state-of-the art techniques to solve mechanisms of environmental toxicity affecting complex diseases in various organ systems. The cutting-edge basic science research programs of 22 Training Grant Faculty members, state-of-the-art technologies developed at the University of Arizona in association with the Southwest Environmental Health Sciences Center and Bio5, and translational approaches undertaken by our NIEHS Superfund Program and US-Mexico Binational Center provide an exceptionally stimulating environment for the training of graduate students and postdoctoral fellows. The interactive research of our Training Grant Faculty and our state-of-the-art Facility Cores extend the training environment from a single laboratory-oriented domain into a multidisciplinary experience strongly supportive of collaborative research. The University provides financial support for first year Ph.D. students, providing a large pool of highly qualified candidates for competitive selection of predoctoral trainees. Predoctoral training is achieved through a combination of coursework, laboratory research, and supplemental enrichment activities. Postdoctoral trainees participate in innovative research programs and are guided to develop professional skills in oral and written communication and in supervision. Over past five years, the curricular changes parallel the evolving expertise of the Training Grant Faculty in utilizing state-of-the-art technology for research projects. We have recruited 3 senior (Professor) and 3 junior (Assistant Professor) faculty into the Training Grant, which significantly enhances the strength in the core of mechanistic based molecular toxicology training. We have opened the Training Grant for University-wide selection to further stimulate interdisciplinary/multidisciplinary approaches in research and training. The request for continuation of NIEHS support is validated by the highly successful nature of our program, the clear demand for our graduates, the strong emphasis we place on leadership skills for our trainees and postdoctoral fellows, the increasing number of students interested in toxicology, substantial institutional commitment, strong and well-funded research programs of our faculty, and the excellence of the training environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007091-33
Application #
8500265
Study Section
Special Emphasis Panel (ZES1-LWJ-J (T3))
Program Officer
Shreffler, Carol K
Project Start
1979-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$487,523
Indirect Cost
$31,913
Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Bashyal, Bharat P; Wijeratne, E M Kithsiri; Tillotson, Joseph et al. (2017) Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus. J Nat Prod 80:427-433
Rojo de la Vega, Montserrat; Krajisnik, Andrea; Zhang, Donna D et al. (2017) Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients 9:
Tillotson, Joseph; Kedzior, Magdalena; GuimarĂ£es, Larissa et al. (2017) ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett 27:4082-4085
Han, JianHua; Dzierlenga, Anika L; Lu, Zhengqiang et al. (2017) Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model. Obesity (Silver Spring) 25:1069-1076
Justiniano, Rebecca; Williams, Joshua D; Perer, Jessica et al. (2017) The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis. Photochem Photobiol 93:990-998
Clarke, John D; Novak, Petr; Lake, April D et al. (2017) Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease. Liver Int 37:1074-1081
Justiniano, Rebecca; Perer, Jessica; Hua, Anh et al. (2017) A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin. Photochem Photobiol 93:1472-1482
Li, Hui; Clarke, John D; Dzierlenga, Anika L et al. (2017) In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. J Biochem Mol Toxicol 31:
Bao, Lingjie; Wu, Jianfa; Dodson, Matthew et al. (2017) ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog 56:1543-1553
Strom, Joshua; Chen, Qin M (2017) Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction. Toxicol Appl Pharmacol 327:52-58

Showing the most recent 10 out of 221 publications