This training grant proposal requests support for 8 pre-doctoral and 4 postdoctoral trainees in environmental toxicology at the University of North Carolina-Chapel Hill (UNC). The proposed Training Program brings together a highly interactive and productive faculty of basic scientists, physician- scientists and public health researchers from the Schools of Medicine, Public Health, and Pharmacy at UNC, plus outstanding researchers and mentors from the EPA, NIEHS and the Hamner Institute in Research Triangle Park. This unique blend of environmental health researchers has worked together for the past 25 years to produce 106 Ph.D. graduates and 63 postdoctoral fellows who have gone on to productive academic, government and private sector positions. To capitalize on this success, this Training Program has undergone extensive critical evaluation that has led to major improvements in administration, faculty-selection, and training approaches. This has resulted in greater cohesiveness, increased co-mentoring, and a focus on interdisciplinary and translational research with critical clinical and public health impact. The proposed training program faculty includes 49 basic researchers, 16 MDs, and 3 epidemiologists with proven research records in environmental health. The faculty conducts research in the areas of molecular carcinogenesis, mechanistic toxicology, cardiopulmonary toxicology, neurotoxicology, hepatotoxicology, computational toxicology, and developmental/-immunotoxicology. The training is focused on interdisciplinary cross-cutting programs in environmental toxicology, systems toxicology, research translation, animal models of human diseases and biomarkers. The program has outstanding didactic instruction, excellent oversight, unparalleled resources, and a superb environment to support the proposed training. Trainees supported by the NIEHS training grant will be engaged in research projects addressing critical environmental health research issues, such as (i) how the environment contributes to toxic injury;(ii) the molecular components of biological systems of protection against cellular damage;(iii) the specific mechanisms involved in response to toxicity and in repair pathways, and (iv) disease outcomes associated with environmental exposures to toxicants. The outstanding new scientists the investigators train will excel at interdisciplinary approaches that improve mechanistic understanding and translate their findings to environmental health. BACKGROUND This is a competing continuation application requesting funding for a Training Program that was initially established in 1979. Funding is requested for eight pre-doctoral trainees and four postdoctoral trainees. Several changes have occurred or are proposed for the leadership of this program. Dr. Swenberg will remain as the Program Director. However, four of the other five key leadership positions have changed. Dr. Ivan Rusyn has assumed the duties of Associate Director. Dr. Richard Mailman has assumed the duties of Director of Postdoctoral Studies. Dr. Marila Cordeiro-Stone has assumed the position of Director of Pre-doctoral Training and Dr. Bernard Weissman has assumed the position of Director of Admissions. Changes have also occurred in the training program faculty. Sixteen faculty members are no longer part of the Training Program and thirty-four faculty members have joined the Training Program. There are currently a total of 69 faculty members participating in the program. Of those forty-seven are on-campus and twenty-one are adjunct faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007126-29
Application #
8101093
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Humble, Michael C
Project Start
1982-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
29
Fiscal Year
2011
Total Cost
$533,481
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Burbank, Allison J; Duran, Charity G; Almond, Martha et al. (2017) A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo. J Allergy Clin Immunol 140:1179-1181.e4
Martin, Elizabeth; Smeester, Lisa; Bommarito, Paige A et al. (2017) Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period. Epigenomics 9:267-278
Bowers, Emma C; McCullough, Shaun D (2017) Linking the Epigenome with Exposure Effects and Susceptibility: The Epigenetic Seed and Soil Model. Toxicol Sci 155:302-314
Huang, Madelyn C; Douillet, Christelle; Su, Mingming et al. (2017) Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Arch Toxicol 91:189-202
Beattie, Matthew C; Maldonado-Devincci, Antoniette M; Porcu, Patrizia et al. (2017) Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3?,5?)3-hydroxypregnan-20-one (3?,5?-THP) in the amygdala of the cynomolgus monkey. Addict Biol 22:318-330
Szabo, David T; Pathmasiri, Wimal; Sumner, Susan et al. (2017) Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture. Environ Health Perspect 125:651-659
Douillet, Christelle; Huang, Madelyn C; Saunders, R Jesse et al. (2017) Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Arch Toxicol 91:2617-2627
Brooks, Samira A; Fry, Rebecca C (2017) Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-?) pathway. Food Chem Toxicol 109:721-726
Winters, Brett R; Pleil, Joachim D; Angrish, Michelle M et al. (2017) Standardization of the collection of exhaled breath condensate and exhaled breath aerosol using a feedback regulated sampling device. J Breath Res 11:047107
Burbank, Allison J; Duran, Charity G; Pan, Yinghao et al. (2017) Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma. J Allergy Clin Immunol :

Showing the most recent 10 out of 439 publications