The toxicology training program at the University of Texas Medical Branch is an interdisciplinary program with a stated focus on the fundamental mechanisms of toxic injury. The program is directed by Dr. Mary Moslen, who devotes 15% effort. She is assisted in program governance by three Associate Directors, who are also chairs of standing committees. These individuals are Drs. Edward Postlethwait (curriculum), Bennett Van Houten (seminar) and Jonathan Ward (recruitment); together with Dr. Moslen, they comprise the Executive Committee. In addition, representatives of each participating graduate programs serve on different standing committees. The training faculty will consist of 26 scientists from the Departments of Experimental Pathology, Human Biological Chemistry and Genetics, Microbiology and Immunology, Pharmacology and Toxicology, Physiology and Biophysics, and Preventive Medicine and Community Health. These department each have their own doctoral programs; candidates for the training grant are drawn from these programs on the basis of interest in toxicology research. Students complete course work in both their home department and core courses within the training program. These core courses include biochemistry and cell biology (also required courses in each of the participating departmental programs), 3 semesters of toxicology seminar, Principles of Drug Action, and Fundamentals of Pathology. A """"""""General Toxicology"""""""" course was dropped due to the perception of overlap in content with other courses. Students are also expected to take a minimum of 1 elective courses on specialized toxicology issues (e.g., hepatic toxicology, cardiovascular toxicology). Emphasis is placed on effective communication and participation in seminars, and local scientific meetings is required. According to the regulations of the host department, students must pass qualifying examinations and successfully prepare and defend a doctoral thesis. Postdoctoral candidates are recruited by the proposed research mentor, and their training is individualized for the specific mentor's research and applicant's background. All are expected to attend the toxicology seminars and participate in meetings and scholarly activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007254-09
Application #
2654603
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1990-07-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
2001-06-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Richardson, Lauren; Menon, Ramkumar (2018) Proliferative, Migratory, and Transition Properties Reveal Metastate of Human Amnion Cells. Am J Pathol 188:2004-2015
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100
Hadley, Emily E; Sheller-Miller, Samantha; Saade, George et al. (2018) Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells. Am J Obstet Gynecol 219:478.e1-478.e21
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner. Toxicol Appl Pharmacol 359:47-54
Dimet, Andrea L; Cisneros, Irma E; Fox, Robert G et al. (2018) A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder. J Vis Exp :
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Promoter Haplotypes of the ABCB1 Gene Encoding the P-Glycoprotein Differentially Affect Its Promoter Activity by Altering Transcription Factor Binding. DNA Cell Biol 37:973-981
Ochoa, Lorenzo F; Kholodnykh, Alexander; Villarreal, Paula et al. (2018) Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep 8:13348
Hao, Wenjing; Qi, Tianyang; Pan, Lang et al. (2018) Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA. Redox Biol 18:43-53
Scala, Federico; Nenov, Miroslav N; Crofton, Elizabeth J et al. (2018) Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway. Cell Rep 23:555-567
Ali, Syed R; Liu, Zhiqing; Nenov, Miroslav N et al. (2018) Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic. ACS Chem Neurosci 9:976-987

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