This is a competing continuation application to renew the Research Training Program in Environmental Toxicology. Established in 2000 to help recruit new scientists into this important discipline, the Program educates pre- and postdoctoral trainees in reproductive, developmental and endocrine toxicology. The need to train students and postdoctoral fellows in these aspects of toxicology is every bit as urgent today as it was 10 years ago when the training program was first conceived. Environmental chemicals that act as endocrine disrupters continue to dominate environmental health concerns. The program unites two long recognized areas of research excellence on the University of Illinois campus, environmental toxicology and reproductive biology, and the investigators can count among their preceptors some of the brightest stars on the University of Illinois campus. Several outstanding new preceptors have joined the Program since the last submission (Flaws, Hofmann) and two additional preceptors are added in this renewal application (Boppart, Freund) resulting in a total of 15 preceptors from seven departments (Animal Sciences, Bioengineering, Chemistry, Crop Sciences, Food Science and Human Nutrition, Molecular and Integrative Physiology and Veterinary Biosciences). Together these faculty currently have over 40 federally funded research grants totaling more than $9 million dollars per year direct costs. The preceptors are researching endocrine active chemicals using a broad multidisciplinary perspective. Collaborations among laboratories working at the molecular, cellular, whole animal and human health levels provide trainees with the unique opportunity to directly observe and participate in translational research. Selection of trainees is based on academic success, relevance of proposed research to Program goals and commitment to toxicology. Preference is given to pre-doctoral trainees in their first or second year of graduate study. The Program offers a broad range of graduate level courses in toxicology. In addition to their departmental requirements, all pre-doctoral trainees take basic toxicology, systems toxicology and at least one other advanced toxicology course related to their field of study. Postdoctoral trainees conduct independent research in toxicology. All trainees are required to attend weekly toxicology research seminars, career development workshops, a toxicology journal club and a course on research ethics in toxicology. Trainees are also required to present their research in the seminar and strongly encouraged to present their research at national meetings. The investigators have a strong record of recruiting and retaining qualified students from underrepresented groups and we will continue and expand these efforts. Relevance: This Training Program will train pre- and postdoctoral students to become the next generation of research scientists in endocrine, developmental and reproductive toxicology, subdisciplines of toxicology that are directly relevant to human health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Illinois Urbana-Champaign
Veterinary Sciences
Schools of Veterinary Medicine
United States
Zip Code
Willing, Jari; Cortes, Laura R; Brodsky, Joseph M et al. (2017) Innervation of the medial prefrontal cortex by tyrosine hydroxylase immunoreactive fibers during adolescence in male and female rats. Dev Psychobiol 59:583-589
Juraska, Janice M; Willing, Jari (2017) Pubertal onset as a critical transition for neural development and cognition. Brain Res 1654:87-94
Rattan, Saniya; Zhou, Changqing; Chiang, Catheryne et al. (2017) Exposure to endocrine disruptors during adulthood: consequences for female fertility. J Endocrinol 233:R109-R129
Barakat, Radwa; Lin, Po-Ching Patrick; Rattan, Saniya et al. (2017) Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice. Toxicol Sci 156:96-108
Patel, Shreya; Brehm, Emily; Gao, Liying et al. (2017) Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study. Endocrinology 158:1727-1738
Pollock, Julie A; Wardell, Suzanne E; Parent, Alexander A et al. (2016) Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. Nat Chem Biol 12:795-801
Boonmuen, Nittaya; Gong, Ping; Ali, Zulfiqar et al. (2016) Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids 105:42-9
Eckstrum, Kirsten S; Weis, Karen E; Baur, Nicholas G et al. (2016) Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A. Endocrinology 157:1408-20
Pisani, Samantha L; Neese, Steven L; Katzenellenbogen, John A et al. (2016) Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner. Endocrinology 157:292-303
Berger, Amelia; Ziv-Gal, Ayelet; Cudiamat, Jonathan et al. (2016) The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice. Reprod Toxicol 60:39-52

Showing the most recent 10 out of 131 publications