Renewal is requested for a training program in bioinformatics at North Carolina State University, support for 8 pre-doctoral trainees and 2 postdoctoral trainees. The application rests on the success of the bioinformatics graduate program at NC State. This program began in the fall of 1999 and has now produced 37 Master of Bioinformatics and 38 Ph.D. in Bioinformatics graduates. The doctoral graduates are in academic or postdoctoral positions, or are working in the pharmaceutical industry. The number of applicants to this program has risen steadily every year. The graduate training program has prerequisites in mathematics, statistics, computing, and genetics. Ph.D. candidates are engaged in coursework in bioinformatics, computer science, genetics or biochemistry, and statistics for two years, and are expected to complete their program within five years. Candidates share some courses and a journal club with candidates in a parallel degree program in functional genomics. In the last few years, the program has recruited more faculty members working in the area of environmental health and human diseases and has now a growing number of students pursuing research training in this area.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
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Environmental Health Sciences Review Committee (EHS)
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Shreffler, Carol K
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North Carolina State University Raleigh
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United States
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Zhang, Guozhu; Truong, Lisa; Tanguay, Robert L et al. (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS One 12:e0169408
Zhang, Guozhu; Roell, Kyle R; Truong, Lisa et al. (2017) A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117
Xue, Shang; Bradbury, Peter J; Casstevens, Terry et al. (2016) Genetic Architecture of Domestication-Related Traits in Maize. Genetics 204:99-113
Zhang, Guozhu; Marvel, Skylar; Truong, Lisa et al. (2016) Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reprod Toxicol 62:92-9
Kollitz, Erin M; Zhang, Guozhu; Hawkins, Mary Beth et al. (2016) Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership. PLoS One 11:e0168278
Kollitz, Erin M; Zhang, Guozhu; Hawkins, Mary Beth et al. (2015) Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates. PLoS One 10:e0122853
Beam, Andrew L; Motsinger-Reif, Alison A; Doyle, Jon (2015) An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics. BioData Min 8:6
Monacell, James T; Carbone, Ignazio (2014) Mobyle SNAP Workbench: a web-based analysis portal for population genetics and evolutionary genomics. Bioinformatics 30:1488-90
Griffing, Alexander R; Lynch, Benjamin R; Stone, Eric A (2014) Structural properties of the minimum cut of partially-supplied graphs. Discrete Appl Math 117:152-157
Beam, Andrew L; Motsinger-Reif, Alison; Doyle, Jon (2014) Bayesian neural networks for detecting epistasis in genetic association studies. BMC Bioinformatics 15:368

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