This is a renewal of the training grant "Training in Molecular Toxicology" at UCLA that was first funded in 2008. The training grant has catalyzed the expansion and consolidation of molecular toxicological research and training at UCLA and has stimulated interactions and collaborations among the participating faculty and the pre- and postdoctoral trainees. During the current funding period, the number of training grant faculty members increased from nine to fourteen. The faculty has primary appointments in nine different departments at UCLA. Four of the new appointees are Assistant Professors, and represent potential future leaders of the program. Seven of the faculty members have M.D. degrees. These faculty provides a potential avenue for the recruitment of physician-scientists to postdoctoral (and perhaps also pre-doctoral) positions in the training grant. The training grant requests support for five years and for four pre-doctoral students in the Molecular Toxicology Interdepartment Doctoral Program (IDP) at UCLA, and two postdoctoral trainees in the laboratories of the training grant faculty. Pre-doctoral trainees wil usually be appointed for three years, and postdoctoral trainees will be appointed for up to two years. In general, only pre-doctoral trainees who have completed their first year (during which most do rotations) will be awarded positions on the training grant. This number of trainee positions requested is justified by the increase in the number of our faculty, their substantial NIEHS and non-NIEHS funding, the investigators'previous success in recruiting excellent pre-doctoral and postdoctoral trainees, and the excellent publication record of the trainees. The faculty has a common interest in the mechanisms whereby environmental toxins cause disease. There are four major foci of research interest: i) The role of pesticides in the etiology of Parkinson's disease, ii) genetic damage (including carcinogenesis) caused by environmental agents, (iii) the toxic effects of secondhand cigarette smoke and of fossil fuels and their combustion products, and iv) nanotoxicology. Other areas of research pursued by individual faculty include metal toxicity and the analysis of transcription networks in toxicity. The UCLA Vice Chancellor for Research very recently announced a "Grand Challenge" initiative. One of the six Challenges focuses on preventing diseases associated with energy, pesticides and environmental technologies. The training grant faculty and trainees are poised to make major contributions to this endeavor. The UCLA Academic Senate undertook an eight year review of the Molecular Toxicology IDP in 2010, and an External Advisory Committee reviewed the training grant in 2011. The Committees were clearly impressed with the IDP and the attainments of the training grant. UCLA has committed considerable resources to the Molecular Toxicology Program, and institutional support is very strong. Over the next five years the NIEHS training grant will further enhance and stimulate molecular toxicological research and training at UCLA, should encourage more students and postdoctoral fellows to pursue research in toxicology, and will signal the increasing importance of toxicology as a discipline at UCLA.

Public Health Relevance

The pre-doctoral and postdoctoral trainees of the training grant in Molecular Toxicology will acquire expertise in how to perform research on the mechanisms whereby environmental pollutants cause disease. Great strides in the identification, appraisal, and amelioration of the toxicological risks of environmental pollutants are likely to emanate from such studies.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32ES015457-06A1
Application #
8667052
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Martin, Ciara A; Myers, Katherine M; Chen, Audrey et al. (2016) Ziram, a pesticide associated with increased risk for Parkinson's disease, differentially affects the presynaptic function of aminergic and glutamatergic nerve terminals at the Drosophila neuromuscular junction. Exp Neurol 275 Pt 1:232-41
Freyberg, Zachary; Sonders, Mark S; Aguilar, Jenny I et al. (2016) Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain. Nat Commun 7:10652
Anderson, Alexander; Laohavisit, Anuphon; Blaby, Ian K et al. (2016) Exploiting algal NADPH oxidase for biophotovoltaic energy. Plant Biotechnol J 14:22-8
Blaby, Ian K; Blaby-Haas, Crysten E; Pérez-Pérez, María Esther et al. (2015) Genome-wide analysis on Chlamydomonas reinhardtii reveals the impact of hydrogen peroxide on protein stress responses and overlap with other stress transcriptomes. Plant J 84:974-88
Ferreira, Daniel W; Allard, Patrick (2015) Models of germ cell development and their application for toxicity studies. Environ Mol Mutagen 56:637-49
Pérez-Martín, Marta; Blaby-Haas, Crysten E; Pérez-Pérez, María Esther et al. (2015) Activation of Autophagy by Metals in Chlamydomonas reinhardtii. Eukaryot Cell 14:964-73
Zones, James Matt; Blaby, Ian K; Merchant, Sabeeha S et al. (2015) High-Resolution Profiling of a Synchronized Diurnal Transcriptome from Chlamydomonas reinhardtii Reveals Continuous Cell and Metabolic Differentiation. Plant Cell 27:2743-69
Blaby, Ian K; Blaby-Haas, Crysten E; Tourasse, Nicolas et al. (2014) The Chlamydomonas genome project: a decade on. Trends Plant Sci 19:672-80
Solaimani, Parrisa; Wang, Feng; Hankinson, Oliver (2014) SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. J Biol Chem 289:33655-62
Martin, Ciara A; Barajas, Angel; Lawless, George et al. (2014) Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure. Neurotoxicology 44:344-51

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