This is a resubmission of a competing renewal application for continued support for a training grant in molecular genetics emphasizing vision research at Baylor College of Medicine. At the time of the last renewal, the program was awarded six pre- and two postdoctoral positions and we are requesting a continuation of the same number of slots. The goal of this proposal is to provide comprehensive training to predoctoral students and postdoctoral fellows in both molecular genetics and visual processes in preparation for careers in vision research. There are 17 training faculty, including Full, Associate, and Assistant Professors. These faculty maintain independent, well-funded laboratories conducting research in both genetics and visual processes. Major areas of research include the molecular genetics of human eye disease, studies of fundamental retinal processes using the mouse, zebrafish, and Drosophila as model organisms, phototransduction, cataract formation, lens and corneal development, and glaucoma. All faculty on this grant actively use genetic techniques to pursue vision research and represent three institutions at the Texas Medical Center. Indeed, the highly interactive, multi-departmental and inter-institutional composition of our faculty is a key strength of our program. Student training comprises a full year of didactic and interactive coursework, journal clubs, and research rotations. In addition, we continue to offer a course entitled """"""""Molecular Genetics in Vision Research"""""""" as well as a bi-monthly research seminar series, the """"""""Houston Eye Club,"""""""" in which graduate students and postdoctoral fellows present their work to a group about 30-40 researchers from more than a dozen vision research laboratories in Houston. Students are expected to remain on this grant for 2-4 years while fellows will usually be supported for 1-2 years during which time they are expected to apply for extramural funding. Predoctoral fellows are also advised and encouraged to apply for predoctoral fellowships when possible. Currently, there are 320 graduate students and 151 postdoctoral fellows eligible for support in the departments associated with this training program. In the last 10 years, 11 graduate students supported by this training grant have received a Ph.D. degree and four of these have continued their careers in vision research. Of the five postdoctorals supported, four are still engaged in vision research. Since many visual system disorders are inherited and there have been recent and significant advances in applying gene therapy to treat retinal disease, training new scientists who are well versed in both genetics and vision research is a top priority of our training program.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
5T32EY007102-19
Application #
8103848
Study Section
Special Emphasis Panel (ZEY1-VSN (06))
Program Officer
Agarwal, Neeraj
Project Start
1988-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
19
Fiscal Year
2011
Total Cost
$263,138
Indirect Cost
Name
Baylor College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Barrasso, Anthony P; Tong, Xuefei; Poché, Ross A (2017) The mito::mKate2 mouse: A far-red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo. Genesis :
Porto, Fernanda B O; Jones, Evan M; Branch, Justin et al. (2017) Molecular Screening of 43 Brazilian Families Diagnosed with Leber Congenital Amaurosis or Early-Onset Severe Retinal Dystrophy. Genes (Basel) 8:
Galaz-Montoya, Monica; Wright, Sara J; Rodriguez, Gustavo J et al. (2017) ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem 292:9967-9974
Boone, Philip M; Yuan, Bo; Gu, Shen et al. (2016) Hutterite-type cataract maps to chromosome 6p21.32-p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death. Mol Genet Genomic Med 4:77-94
Xu, Mingchu; Gelowani, Violet; Eblimit, Aiden et al. (2015) ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement. Invest Ophthalmol Vis Sci 56:3889-95
Ge, Zhongqi; Bowles, Kristen; Goetz, Kerry et al. (2015) NGS-based Molecular diagnosis of 105 eyeGENE(®) probands with Retinitis Pigmentosa. Sci Rep 5:18287
Xu, Mingchu; Yang, Lizhu; Wang, Feng et al. (2015) Mutations in human IFT140 cause non-syndromic retinal degeneration. Hum Genet 134:1069-78
Zaneveld, Jacques; Siddiqui, Sorath; Li, Huajin et al. (2015) Comprehensive analysis of patients with Stargardt macular dystrophy reveals new genotype-phenotype correlations and unexpected diagnostic revisions. Genet Med 17:262-70
Salvo, Jason; Lyubasyuk, Vera; Xu, Mingchu et al. (2015) Next-generation sequencing and novel variant determination in a cohort of 92 familial exudative vitreoretinopathy patients. Invest Ophthalmol Vis Sci 56:1937-46
Sandoval, Ivette M; Price, Brandee A; Gross, Alecia K et al. (2014) Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS One 9:e108135

Showing the most recent 10 out of 69 publications