Faculty of three contiguous institutions, Weill Cornell Medical College (WCMC), Sloan-Kettering Institute (SKI), and The Rockefeller University (RU), request funds to continue a collaborative tri-institutional training program in vision research (TTPVR) started fourteen years ago. The current TTPVR consists of an integrated set of training activities for PhD students and postdoctoral fellows. The strengths and diversities of the faculties provide opportunities for research in retinal cell and developmental biology, genetics, neural regeneration, development and plasticity, immunology, structural biology, signal transduction, and information processing at the level of the eye and the brain. The various research projects utilize a vast array of methodologies, such as molecular and cell biology, yeast and mouse genetics, gene transfer and gene therapy, crystallography and other structural approaches, electrophysiology, imaging, high resolution optical microscopy, behavior, computer modeling, and epidemiology. The pooling of resources for vision training leads to an enrichment of programs over and above those available at the individual institutions, promotes collaborations between participating basic science faculty, as well as with clinical faculty, and provides a unique opportunity for the hiring of new Vision Faculty or attracting existing faculty into Vision Research. Interaction between Program Faculty and students takes place via a Vision seminar series, a weekly Vision journal club, a course by clinical-academic faculty designed to expose basic vision scientists to vision disorders seen in the clinic, various other courses dealing with different aspects of vision research, 3 times per year meetings of the New York Vision Research Club attended by members of three NIH-funded Vision Training Programs in the city and an annual post-ARVO poster session. This intense exposure provides a vehicle for a keener understanding of clinical problems and for the selection of research areas that unite clinical and basic scientists in the quest to cure blinding diseases. The request for NIH support of a proposed Tri-lnstitutional Training Program in Vision Research builds on major commitments by the three participating institutions of faculty, funds and research space devoted to vision research.

Public Health Relevance

The TTPVR will train pre-doctoral and post-doctoral fellows in a broad range of areas relevant to Vision Research, including translational aspects relevant to the study and treatment of eye diseases. Therefore, we expect that it will contribute significantly to forming researchers that will be able to contribute novel approaches to investigate and treat blinding diseases in the future.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
5T32EY007138-19
Application #
8311767
Study Section
Special Emphasis Panel (ZEY1-VSN (06))
Program Officer
Agarwal, Neeraj
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
19
Fiscal Year
2012
Total Cost
$198,104
Indirect Cost
$13,110
Name
Weill Medical College of Cornell University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Goren, Michael A; Morizumi, Takefumi; Menon, Indu et al. (2014) Constitutive phospholipid scramblase activity of a G protein-coupled receptor. Nat Commun 5:5115
Dreyfuss, Michael; Caudle, Kristina; Drysdale, Andrew T et al. (2014) Teens impulsively react rather than retreat from threat. Dev Neurosci 36:220-7
Schiff, N D; Shah, S A; Hudson, A E et al. (2013) Gating of attentional effort through the central thalamus. J Neurophysiol 109:1152-63
Nichols, Zachary; Nirenberg, Sheila; Victor, Jonathan (2013) Interacting linear and nonlinear characteristics produce population coding asymmetries between ON and OFF cells in the retina. J Neurosci 33:14958-73
Grunbeck, Amy; Huber, Thomas; Sachdev, Pallavi et al. (2011) Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers. Biochemistry 50:3411-3
Miri, Andrew; Daie, Kayvon; Arrenberg, Aristides B et al. (2011) Spatial gradients and multidimensional dynamics in a neural integrator circuit. Nat Neurosci 14:1150-9
Miri, Andrew; Daie, Kayvon; Burdine, Rebecca D et al. (2011) Regression-based identification of behavior-encoding neurons during large-scale optical imaging of neural activity at cellular resolution. J Neurophysiol 105:964-80
Menzer, David L; Bokil, Hemant; Ryou, Jae Wook et al. (2010) Characterization of trial-to-trial fluctuations in local field potentials recorded in cerebral cortex of awake behaving macaque. J Neurosci Methods 186:250-61
Schreiner, Ryan; Frindt, Gustavo; Diaz, Fernando et al. (2010) The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Kidney Int 78:382-8
Hudson, Andrew E; Schiff, Nicholas D; Victor, Jonathan D et al. (2009) Attentional modulation of adaptation in V4. Eur J Neurosci 30:151-71

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