It clearly emerges from """"""""Vision Research;A National Plan"""""""" that vision research embraces every discipline in the biological sciences, cognitive sciences, and clinical research. Vision scientists are aware of the importance of the interdisciplinary approach to research, and of rapid translation of findings in basic research to clinical care. Accordingly, the next generation of vision scientists will need to develop their scientific skills within an environment that stresses cutting edge science, interdisciplinary cooperation, an understanding of the visual system, and exposure to clinical ophthalmology. This training program, while broad in the scope of participating scientific disciplines, is focused on creating at the University of Pittsburgh a training environment that will favor interactions and collaborations among vision scientists, and involve pre-doctoral students and postdoctoral fellows in interdisciplinary approaches to understanding the visual system and ocular diseases. Although this T32 application focuses on training of basic scientists, our trainees will have frequent interactions with clinical ophthalmologists, attend lecturers in our didactic vision cours entitled """"""""Biology of Vision"""""""", and have close interactions with physician-scientists through course work, seminars, and data clubs. Our T32 training program will draw graduate students from the Immunology, Molecular Virology and Microbiology, Neuroscience, Cell Biology and Molecular Physiology, and Bioengineering graduate training programs. These programs will provide the structure and basic curriculum, whereas the T32 training program will provide specialized training in vision research. The proposed program will also provide a structure for training of postdoctoral fellows in vision research that will coordinate with the significant support structure already in place at the university. We will strive to attract the brightest students and postdocs with the goals of providing 1) a basic understanding of the anatomy, physiology, and diseases of the eye;2) appreciation and utilization of the unique anatomical and physiological characteristics of the eye;and 3) awareness of the strengths and limitations of available animal models for ocular diseases.

Public Health Relevance

Training students and postdoctoral fellows in vision research provides the next generation of vision scientists who will study the visual system in health and disease. This IVS training program will encourage the involvement of young scientists in vision research by providing structure and support for the training of graduate students and postdoctoral fellows in the visual sciences.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Institutional National Research Service Award (T32)
Project #
2T32EY017271-06A1
Application #
8665248
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Agarwal, Neeraj
Project Start
2006-04-01
Project End
2019-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Jan, Ning-Jiun; Brazile, Bryn L; Hu, Danielle et al. (2018) Crimp around the globe; patterns of collagen crimp across the corneoscleral shell. Exp Eye Res 172:159-170
Tran, Huong; Wallace, Jacob; Zhu, Ziyi et al. (2018) Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head. Invest Ophthalmol Vis Sci 59:2564-2575
Murphy, Matthew C; Chan, Kevin C; Kim, Seong-Gi et al. (2018) Macroscale variation in resting-state neuronal activity and connectivity assessed by simultaneous calcium imaging, hemodynamic imaging and electrophysiology. Neuroimage 169:352-362
Brazile, Bryn L; Hua, Yi; Jan, Ning-Jiun et al. (2018) Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams. Invest Ophthalmol Vis Sci 59:4653-4661
Hua, Yi; Voorhees, Andrew P; Sigal, Ian A (2018) Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics. Invest Ophthalmol Vis Sci 59:154-165
Voorhees, Andrew P; Jan, Ning-Jiun; Hua, Yi et al. (2018) Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications. Acta Biomater 79:113-122
Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2018) Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. Sci Rep 8:7281
Stella, Nicholas A; Brothers, Kimberly M; Callaghan, Jake D et al. (2018) An IgaA/UmoB Family Protein from Serratia marcescens Regulates Motility, Capsular Polysaccharide Biosynthesis, and Secondary Metabolite Production. Appl Environ Microbiol 84:
Yang, Bin; Jan, Ning-Jiun; Brazile, Bryn et al. (2018) Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues. J Biophotonics 11:e201700356
Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2017) Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes. Sci Rep 7:9930

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