Vision research now spans basic science (biology, chemistry, computer science, genetics, optics) but also has strong traditional links to neuroscience and newly evolving aspects of translational research in ocular disease. The principle underlying graduate education at the University of Utah is that students learn basic research and applied vision science, and experience strong interdisciplinary, interdepartmental collaborations. Predoctoral and postdoctoral trainees are endowed with skills ranging over molecular biology, electrophysiology, developmental neuroscience, retinal connectomics, translational science and visual behavior. These diverse approaches are unified by training in two intellectual streams that represent the core strengths of the Moran Vision Institute and the vision research community at the University of Utah: the study of human disease, a tradition of excellence in the cutting-edge praxis molecular biology, physiology and connectomics. Eighteen NIH/NEI-funded training faculty members are aligned in five broad areas of vision research: Molecular and Cellular Science, Developmental Science, Ocular Disease, Translational Interventions, and Computational Science. These areas reflect the breadth of the program and provide exceptional opportunities to the 74 current predoctoral and postdoctoral trainees. This application requests funding for 2 predoctoral and 4 postdoctoral trainees. Due to the outstanding, accredited predoctoral training programs already in place, recent graduates University of Utah have been placed in excellent postdoctoral fellowships at Yale, Stanford, Harvard, U Mass, UCSD, and UCSF. Our postdoctoral trainees have published widely, taken faculty positions, received Research to Prevent Blindness Career Development Awards, and are competing successfully for NIH RO1 funding. We believe that trainees from our Vision Research Training Program will become future leaders in vision research.

Public Health Relevance

Vision research spans a vast range of basic science areas (biology, chemistry, computer science, genetics, optics) with strong traditional links to neuroscience and newly evolving dimensions in translational research on ocular diseases. The principle underlying vision research training at the University of Utah is that students learn both basic research and applied vision science in their most vivid and advanced forms, and experience strong interdisciplinary, interdepartmental collaborations. We believe that our proposed Vision Research Training Program provides an exceptional format for training future leaders in vision research.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
1T32EY024234-01
Application #
8664688
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Agarwal, Neeraj
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Utah
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Ryskamp, Daniel A; Frye, Amber M; Phuong, Tam T T et al. (2016) TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep 6:30583
Cheng, Haixia; Burroughs-Garcia, Jessica; Birkness, Jacqueline E et al. (2016) Disparate Regulatory Mechanisms Control Fat3 and P75NTR Protein Transport through a Conserved Kif5-Interaction Domain. PLoS One 11:e0165519
Bosco, Alejandra; Breen, Kevin T; Anderson, Sarah R et al. (2016) Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp Eye Res 150:34-43
Molnár, Tünde; Yarishkin, Oleg; Iuso, Anthony et al. (2016) Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci 36:3184-98
Lauritzen, J Scott; Sigulinsky, Crystal L; Anderson, James R et al. (2016) Rod-cone crossover connectome of mammalian bipolar cells. J Comp Neurol :
Iuso, Anthony; Križaj, David (2016) TRPV4-AQP4 interactions 'turbocharge' astroglial sensitivity to small osmotic gradients. Channels (Austin) 10:172-4
Sigulinsky, Crystal L; German, Massiell L; Leung, Amanda M et al. (2015) Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells. Neural Dev 10:12
Marc, Robert E; Anderson, James R; Jones, Bryan W et al. (2014) The AII amacrine cell connectome: a dense network hub. Front Neural Circuits 8:104
Bosco, Alejandra; Steele, Michael R; Vetter, Monica L (2011) Early microglia activation in a mouse model of chronic glaucoma. J Comp Neurol 519:599-620