The postdoctoral training program is designed to train a new generation of investigators with the cross-disciplinary skills needed to conduct future, independent programs in injury- related research. The training program began in 1975 in association with the NIGMS P50 Burn Trauma Center at MGH and the primary research and training activities remain within the Burn Trauma Center. The program has evolved during the last decade to include bioengineering applications for injury care through inclusion of the MGH Center for Engineering in Medicine. Expanded training opportunities in genomic technologies and computational analysis have been added to the program through collaboration with the NIGMS U54 Glue Grant Program. The training faculty is a balance of clinical and basic science faculty from Harvard, Massachusetts Institute of Technology, and Stanford with existing collaborations in the areas of burn injury, metabolism, bioengineering, and computational genomics. Through the collaborative and broad infrastructure that transcends institutional and disciplinary boundaries, the trainee is provided with the opportunity to learn fundamental principles of life sciences and engineering as well as computational genomics and proteomics, and to weave them into the trainee's own investigation of a cutting-edge biomedical problem. Although the training program is tailored to meet the needs of each trainee, formal academic classes (at Harvard/MIT or Stanford) in molecular techniques and tailored classes in responsible conduct of research and survival skills are required in the training program. In addition, the trainee is required to participate in journal clubs, research seminars, and established research meetings. Exposure to clinical care of acutely injured patients is provided through participation in clinical conferences at MGH and Shriners Burn Hospital. The trainee is under the supervision of a faculty trainer who, in turn, is responsible to the research training executive committee to ensure that the trainee is provided with a well-integrated, educational and research program coordinated with clinical medicine. The curriculum ensures that the trainee can complete the program within three years. Preference is given to candidates with an MD degree although PhD candidates with exceptional abilities and motivation are considered.

Public Health Relevance

A new breed of creative, well-versed investigators will learn clinical issues and techniques for modern injury research. For the next generation of investigators, this program will emphasize the integration of genomic and other high-throughput molecular data, and clinical information of patients with the promise of earlier disease detection, prediction of patient outcome trajectories, and identification of targets for interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007035-38
Application #
8690850
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Somers, Scott D
Project Start
1978-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
38
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Zhao, Gaofeng; Yu, Yong-Ming; Kaneki, Masao et al. (2015) Simvastatin reduces burn injury-induced splenic apoptosis via downregulation of the TNF-α/NF-κB pathway. Ann Surg 261:1006-12
Tompkins, Ronald G (2015) Survival from burns in the new millennium: 70 years' experience from a single institution. Ann Surg 261:263-8
Jones, Caroline N; Moore, Molly; Dimisko, Laurie et al. (2014) Spontaneous neutrophil migration patterns during sepsis after major burns. PLoS One 9:e114509
MS-SIG 2013 Organizers; Ryu, So Young; Payne, Samuel H et al. (2014) Beyond the proteome: Mass Spectrometry Special Interest Group (MS-SIG) at ISMB/ECCB 2013. Bioinformatics 30:2089-90
Zhao, Gaofeng; Yu, Yong-Ming; Shoup, Timothy M et al. (2014) Membrane potential-dependent uptake of 18F-triphenylphosphonium--a new voltage sensor as an imaging agent for detecting burn-induced apoptosis. J Surg Res 188:473-9
Sigdel, Tara K; Salomonis, Nathan; Nicora, Carrie D et al. (2014) The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics. Mol Cell Proteomics 13:621-31
Ryu, So Young (2014) Bioinformatics tools to identify and quantify proteins using mass spectrometry data. Adv Protein Chem Struct Biol 94:1-17
Ryu, So Young; Qian, Wei-Jun; Camp, David G et al. (2014) Detecting differential protein expression in large-scale population proteomics. Bioinformatics 30:2741-6
Kurihara, Tomohiro; Jones, Caroline N; Yu, Yong-Ming et al. (2013) Resolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J 27:2270-81
Zhao, Gaofeng; Yu, Yong-Ming; Kaneki, Masao et al. (2013) Simvastatin protects hepatocytes from apoptosis by suppressing the TNF-α/caspase-3 signaling pathway in mice with burn injury. Ann Surg 257:1129-36

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