The goals of the Predoctoral Training Program in Genetics and Development are: to provide a solid and broad education in genetics, including molecular genetics, developmental genetics, and human genetics;to provide rigorous training in research;to develop a scholarly, professional attitude in the trainees. The program emphasizes experimental skills and critical thinking, as well as written and oral presentation of ideas and research findings. We take care to teach our students a rigorous scientific approach in the design of experiments and evaluation of data, and to maintain the highest ethical standards in their work. We encourage students to give and receive constructive criticism and challenge them to be self- critical in order to become capable, independent scholars. A Training Committee oversees administration of the program and monitors student progress through regular meetings and written reports of rotations, qualifying exams and thesis research advisory committees. There are currently 37 trainees.
We aim to recruit 6-8 new trainees each year. The duration of training is typically 6-6.5 years. Training consists of two years of didactic course work in prokaryotic and eukaryotic molecular genetics, biochemistry, developmental genetics, statistics, genetic approaches to biomedical problems, and responsible conduct in research. Three research rotations are done in the first year followed by research in a laboratory of choice. Students have a wide range of research opportunities across the entire Columbia University Medical Center Campus. A two-part qualifying examination in the second and third years takes the form of a research proposal that is defended in a written and oral examination, followed approximately 6 months later by a progress report, similarly defended in a written and oral examination. Students run their own internal seminar program and also participate in the regular departmental seminar series by inviting outside speakers. There is an annual retreat where all trainees are expected to present their work either as a platform presentation or a poster. During the course of training there are milestones at which the MA and MPhil degrees are awarded. With the successful defense of a research thesis, the PhD degree is awarded.

Public Health Relevance

The program goal is to train the next generation of biomedical researchers in areas of genetics and development with special reference to genetic influences on human health, development and disease. The research training includes a variety of basic and diseases-related areas with genetic components including cancer, diabetes, congenital defects, and heart and kidney disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007088-37
Application #
8016867
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1975-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
37
Fiscal Year
2011
Total Cost
$353,504
Indirect Cost
Name
Columbia University (N.Y.)
Department
Genetics
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Billon, Pierre; Bryant, Eric E; Joseph, Sarah A et al. (2017) CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons. Mol Cell 67:1068-1079.e4
Smith, Michael J; Rothstein, Rodney (2017) Poetry in motion: Increased chromosomal mobility after DNA damage. DNA Repair (Amst) 56:102-108
De Tullio, Luisina; Kaniecki, Kyle; Kwon, Youngho et al. (2017) Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation. Cell Rep 21:570-577
Grajkowska, Lucja T; Ceribelli, Michele; Lau, Colleen M et al. (2017) Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification. Immunity 46:65-77
Patel, Tulsi; Hobert, Oliver (2017) Coordinated control of terminal differentiation and restriction of cellular plasticity. Elife 6:
O'Connor, Reed M; Stone, Elizabeth F; Wayne, Charlotte R et al. (2017) A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. J Cell Biol 216:595-605
Coleman, Rory T; Struhl, Gary (2017) Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene. Science 356:
Zhuravlev, Yelena; Hirsch, Sophia M; Jordan, Shawn N et al. (2017) CYK-4 regulates Rac, but not Rho, during cytokinesis. Mol Biol Cell 28:1258-1270
Sallee, Maria D; Littleford, Hana E; Greenwald, Iva (2017) A bHLH Code for Sexually Dimorphic Form and Function of the C. elegans Somatic Gonad. Curr Biol 27:1853-1860.e5
Stupnikov, Maria R; Cardoso, Wellington V (2017) Sensing oxygen inside and out. Elife 6:

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