The present proposal requests funding for years thirty five through forty for the Pharmacological Sciences Training Program at Duke University. The goal of this training program is to prepare Ph.D. candidates from a variety of disciplines to use Pharmacology in their careers as active research scientists in leadership roles. Trainees in the program are pre-doctoral students in biomedical sciences. The program provides classroom training in the basic principles of drug action from the molecular to organismal level and the application of these principles to the treatment of human disease. The research component trains students to conduct cutting-edge research in an area relevant to Pharmacology. Throughout both the classroom and research phase of the pre-doctoral program, trainees participate in research retreats, receive mentoring and ethics training and professional development opportunities. The program requests funding for 2 years of pre-doctoral graduate studies for 10 trainees.
The goal of this training is to prepare Ph.D. candidates to participate in the field of Pharmacology. Graduates of this program will be able to invent new medicines, study the adverse effects of current medicines and develop an understanding of disease and how to treat it.
|Burg, Jonathan M; Gonzalez, Julie J; Maksimchuk, Kenneth R et al. (2016) Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. Biochemistry 55:1652-62|
|Kishton, Rigel J; Barnes, Carson E; Nichols, Amanda G et al. (2016) AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab 23:649-62|
|Hosios, Aaron M; Hecht, Vivian C; Danai, Laura V et al. (2016) Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell 36:540-9|
|Johnson, Marc O; Siska, Peter J; Contreras, Diana C et al. (2016) Nutrients and the microenvironment to feed a T cell army. Semin Immunol 28:505-513|
|Jaeger, Alex M; Pemble 4th, Charles W; Sistonen, Lea et al. (2016) Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors. Nat Struct Mol Biol 23:147-54|
|Howe, Matthew K; Speer, Brittany L; Hughes, Philip F et al. (2016) An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. Antiviral Res 130:81-92|
|Baker, Joseph B; Kim, Hyoungsu; Hong, Jiyong (2015) Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction. Tetrahedron Lett 56:3120-3122|
|Burg, Jonathan M; Link, Jennifer E; Morgan, Brittany S et al. (2015) KDM1 class flavin-dependent protein lysine demethylases. Biopolymers 104:213-46|
|Burg, Jonathan M; Makhoul, Alan T; Pemble 4th, Charles W et al. (2015) A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity. FEBS Lett 589:2340-6|
|Reinardy, Jessica L; Corey, Daniel M; Golzio, Christelle et al. (2015) Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. PLoS One 10:e0139614|
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