This project will support the training of eight students annually at Brandeis University in the field of genetics, most of whom will be appointed in the second year of their Ph. D. training. Students will be engaged in genetics research relating to molecular, cell, and developmental biology and neuroscience, with relevance to the mechanisms and treatment of human disease. The Training Grant Faculty are drawn from highly collaborative and interdisciplinary researchers in the Departments of Biology, Biochemistry and Chemistry. Students work in well-funded and productive laboratories that are supported by recently upgraded core facilities in DNA and protein analysis, proteomics, genomics, microscopy and mouse and viral transgenics. The proposed program emphasizes rigorous training to develop research and other skills including scientific literacy, writing and oal communication and quantitative approaches. The Ph. D. program has a core curriculum of molecular biology, cell biology and ethics and advanced genetics courses, which includes molecular genetics, neurogenetics, population genetics and genomics, epigenetics and human genetics. These core courses are supplemented by elective courses in biochemistry, structural biology, developmental biology, mathematical modeling or neuroscience and courses concerning human diseases such as cancer, infectious disease, neurological and development disorders. Trainees are appointed based on the strength of their academic records and research potential and are supported for two years. Their progress is closely monitored by a committee of Training Grant Faculty selected for each student. Qualifying examinations at the end of the first and second years provide a means to evaluate each student's ability to frame questions and propose research solutions in their emerging area of expertise and in an outside field. The training of students is supplemented by seminars and journal clubs, featuring a wide variety of successful investigators in diverse areas of biological research. Professional development activities feature individual development plans and valuable personal discussions that assist each student's career planning. A new facet of the program is the expansion of skills workshops, aimed at enhancing trainees' master of specific quantitative approaches and fellowship/grant writing skills. Special opportunities for Trainees include enhanced personal interactions with speakers and participation in an annual Genetics Symposium. In addition, Trainees work with Training faculty in the planning and implementation of these activities. The program is assessed yearly through online surveys and personal discussions with Trainees. This, and the small size and interconnectedness of students and faculty, provides training responsive to the needs of each student in a first-class research setting.
This project trains eight Ph. D. students yearly in the field of genetics at Brandeis University. Along with intensive coursework and research training, students work on basic mechanisms of disease and its treatment, including neurodegeneration, developmental disorders, heart disease, cancer and infectious disease. This training features the development of skills necessary for students to become productive and independent contributors in the fields of scientific and medical research, education and biotechnology.
| Gallagher, Danielle N; Haber, James E (2018) Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing. ACS Chem Biol 13:397-405 |
| Hilton, Denise M; Aguilar, Rey M; Johnston, Adam B et al. (2018) Species-Specific Functions of Twinfilin in Actin Filament Depolymerization. J Mol Biol 430:3323-3336 |
| Lemos, Brenda R; Kaplan, Adam C; Bae, Ji Eun et al. (2018) CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles. Proc Natl Acad Sci U S A 115:E2040-E2047 |
| Goodwin, Patricia R; Meng, Alice; Moore, Jessie et al. (2018) MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila. Cell Rep 23:3776-3786 |
| Garabedian, Mikael V; Stanishneva-Konovalova, Tatiana; Lou, Chenyu et al. (2018) Integrated control of formin-mediated actin assembly by a stationary inhibitor and a mobile activator. J Cell Biol 217:3512-3530 |
| O'Donnell, Michael P; Khan, Munzareen; Sengupta, Piali (2018) Thermosensation: Human Parasitic Nematodes Use Heat to Hunt Hosts. Curr Biol 28:R795-R798 |
| Johnston, Adam B; Hilton, Denise M; McConnell, Patrick et al. (2018) A novel mode of capping protein-regulation by twinfilin. Elife 7: |
| Laranjo, Laura T; Gross, Stephen J; Zeiger, Danna M et al. (2017) SSB recruitment of Exonuclease I aborts template-switching in Escherichia coli. DNA Repair (Amst) 57:12-16 |
| Vasudevan, Deepika; Clark, Nicholas K; Sam, Jessica et al. (2017) The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection. Cell Rep 21:2039-2047 |
| Botchkarev Jr, Vladimir V; Garabedian, Mikael V; Lemos, Brenda et al. (2017) The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis. Mol Biol Cell 28:1011-1020 |
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