This renewal application requests continued funding of a predoctoral training program in cellular and molecular biology at Yale University. Since its inception in 1975, the goal of the program has been to provide trainees with both a strong intellectual foundation through coursework and rigorous experimental training in research areas that take molecular and mechanistic approaches to a broad range of basic biological problems. Students and faculty participating in this training program are from several departments, including the main undergraduate campus and the School of Medicine. Thus, the training program fosters connections that transcend departmental boundaries. Much of the research carried out by our students has clear relevance to human health and disease. Students supported by the training program will be in their first, second, or third year of graduate school. The students arrive at Yale as members of the campus-wide Combined Program in the Biological and Biomedical Sciences (BBS). They come with a range of backgrounds in biology, biochemistry, chemistry, genetics, molecular biology and physics, and all students have had significant research experience before graduate school. In their first year, students will take courses that provide general knowledge in disciplines related to cellular and molecular biology and a conceptual grounding for critical evaluation of research design and methods. Students will also carry out research rotations in at least three laboratories selected according to their research interests. By the end of the first year, students will choose their thesis research advisor and affiliate with an appropriate academic department. During the second year, academic requirements for candidacy in the Ph.D. degree will be completed, including a qualifying exam in which the student prepares and defends a thesis proposal. By the third year, a thesis advisory committee will be assembled to guide each student to the completion of his or her Ph.D. training. Teaching experience is an essential part of training, and all students teach with supervision and guidance from the faculty. The average time to graduation is six years.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007223-37
Application #
8098909
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1990-07-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
37
Fiscal Year
2011
Total Cost
$1,679,144
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Budenholzer, Lauren; Cheng, Chin Leng; Li, Yanjie et al. (2017) Proteasome Structure and Assembly. J Mol Biol 429:3500-3524
Park, Sangbum; Gonzalez, David G; Guirao, Boris et al. (2017) Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat Cell Biol 19:155-163
Yartseva, Valeria; Takacs, Carter M; Vejnar, Charles E et al. (2017) RESA identifies mRNA-regulatory sequences at high resolution. Nat Methods 14:201-207
Herzel, Lydia; Ottoz, Diana S M; Alpert, Tara et al. (2017) Splicing and transcription touch base: co-transcriptional spliceosome assembly and function. Nat Rev Mol Cell Biol 18:637-650
Willer, Margaret K; Carroll, Christopher W (2017) Substrate stiffness-dependent regulation of the SRF-Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin. J Cell Sci 130:2111-2118
Taguchi, Yumiko V; Liu, Jun; Ruan, Jiapeng et al. (2017) Glucosylsphingosine Promotes ?-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. J Neurosci 37:9617-9631
Ogawa, L M; Baserga, S J (2017) Crosstalk between the nucleolus and the DNA damage response. Mol Biosyst 13:443-455
Brown, Samara; Pineda, Cristiana M; Xin, Tianchi et al. (2017) Correction of aberrant growth preserves tissue homeostasis. Nature 548:334-337
Salazar, Santiago V; Gallardo, Christopher; Kaufman, Adam C et al. (2017) Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci 37:9207-9221
Arachchilage, Gayan Mirihana; Sherlock, Madeline E; Weinberg, Zasha et al. (2017) SAM-VI RNAs Selectively Bind S-adenosylmethionine and Exhibit Similarities to SAM-III Riboswitches. RNA Biol :0

Showing the most recent 10 out of 443 publications