This renewal application requests continued funding of a predoctoral training program in cellular and molecular biology at Yale University. Since its inception in 1975, the goal of the program has been to provide trainees with both a strong intellectual foundation through coursework and rigorous experimental training in research areas that take molecular and mechanistic approaches to a broad range of basic biological problems. Students and faculty participating in this training program are from several departments, including the main undergraduate campus and the School of Medicine. Thus, the training program fosters connections that transcend departmental boundaries. Much of the research carried out by our students has clear relevance to human health and disease. Students supported by the training program will be in their first, second, or third year of graduate school. The students arrive at Yale as members of the campus-wide Combined Program in the Biological and Biomedical Sciences (BBS). They come with a range of backgrounds in biology, biochemistry, chemistry, genetics, molecular biology and physics, and all students have had significant research experience before graduate school. In their first year, students will take courses that provide general knowledge in disciplines related to cellular and molecular biology and a conceptual grounding for critical evaluation of research design and methods. Students will also carry out research rotations in at least three laboratories selected according to their research interests. By the end of the first year, students will choose their thesis research advisor and affiliate with an appropriate academic department. During the second year, academic requirements for candidacy in the Ph.D. degree will be completed, including a qualifying exam in which the student prepares and defends a thesis proposal. By the third year, a thesis advisory committee will be assembled to guide each student to the completion of his or her Ph.D. training. Teaching experience is an essential part of training, and all students teach with supervision and guidance from the faculty. The average time to graduation is six years.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007223-39
Application #
8501473
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1990-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
39
Fiscal Year
2013
Total Cost
$1,607,564
Indirect Cost
$76,412
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Mirihana Arachchilage, Gayan; Sherlock, Madeline E; Weinberg, Zasha et al. (2018) SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches. RNA Biol 15:371-378
Ma, Mengxiao; Kumar, Santosh; Purushothaman, Latha et al. (2018) Lipid trafficking by yeast Snx4 family SNX-BAR proteins promotes autophagy and vacuole membrane fusion. Mol Biol Cell 29:2190-2200
Ziegler, Samantha J; Liu, Chang; Landau, Mark et al. (2018) Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. PLoS One 13:e0195048
Ma, Natalie Jing; Hemez, Colin F; Barber, Karl W et al. (2018) Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue. Elife 7:
Deng, Yongqiang; Pakdel, Mehrshad; Blank, Birgit et al. (2018) Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Dev Cell 47:464-478.e8
Bello, Oscar D; Jouannot, Ouardane; Chaudhuri, Arunima et al. (2018) Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis. Proc Natl Acad Sci U S A 115:E7624-E7631
Wong, Emily V; Gray, Shawn; Cao, Wenxiang et al. (2018) Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release. J Mol Biol 430:2080-2095
Scanlon, Susan E; Hegan, Denise C; Sulkowski, Parker L et al. (2018) Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. Oncotarget 9:4647-4660
Vallery, Tenaya K; Withers, Johanna B; Andoh, Joana A et al. (2018) Kaposi's Sarcoma-Associated Herpesvirus mRNA Accumulation in Nuclear Foci Is Influenced by Viral DNA Replication and Viral Noncoding Polyadenylated Nuclear RNA. J Virol 92:
Penfield, Lauren; Wysolmerski, Brian; Mauro, Michael et al. (2018) Dynein-pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair. Mol Biol Cell :

Showing the most recent 10 out of 511 publications