Case Western Reserve University School of Medicine (CWRU SOM) has provided outstanding MD/PhD training since 1956. The program has a strong track record with many alumni with distinguished research careers, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training (MST) program was started in 1975 (T32 GM07250) and has 92 current students. The curriculum integrates scientific and clinical instruction with both PhD and MD course work during the first two years, personalized clinical instruction as well as research during the PhD years, core clinical clerkships, and elective time for research and clinical experiences in the final year. Criteria for acceptance include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MST program automatically admits a student to the SOM and any MST [program-affiliated PhD program, including 11 graduate programs based in the SOM plus Biomedical Engineering, Mechanical and Aerospace Engineering, Biology and Chemistry. PhD mentors are subjected to rigorous review by the MST program Steering Committee and provide individualized research training. All active mentors have established training records and are well supported by NIH research grants and other funding sources. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals of Cleveland, Cleveland Clinic Foundation, Metro Health Medical Center and the Louis Stokes Veteran's Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. All CWRU students receive full financial support for stipend, tuition and health fees for all phases of the program (8 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MST program-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities. Relevance: Overall, the program integrates clinical and scientific training of physician scientists in basic biomedical sciences and translational fields;training in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD/PhD students for outstanding careers in biomedical research to fill the national need for future physician-scientists.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Preusch, Peter C
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Case Western Reserve University
Schools of Medicine
United States
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Shaw, Kendrick M; Lyttle, David N; Gill, Jeffrey P et al. (2015) The significance of dynamical architecture for adaptive responses to mechanical loads during rhythmic behavior. J Comput Neurosci 38:25-51
Acquavella, Nicolas; Clever, David; Yu, Zhiya et al. (2015) Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest. Cancer Immunol Res 3:37-47
Ignatz-Hoover, J J; Wang, H; Moreton, S A et al. (2015) The role of TLR8 signaling in acute myeloid leukemia differentiation. Leukemia 29:918-26
Narayan, Sreenath; Flask, Chris A; Kalhan, Satish C et al. (2015) Hepatic fat during fasting and refeeding by MRI fat quantification. J Magn Reson Imaging 41:347-53
Taylor, Patricia R; Roy, Sanhita; Leal Jr, Sixto M et al. (2014) Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORýýt and dectin-2. Nat Immunol 15:143-51
Sundermeier, Thomas R; Jin, Hui; Kleinjan, Matthew L et al. (2014) Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry 53:5831-3
Ishii, Daisuke; Rosenblum, Joshua M; Nozaki, Taiji et al. (2014) Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts. J Immunol 193:3816-24
Martin, Bradley N; Wang, Chenhui; Willette-Brown, Jami et al. (2014) IKK? negatively regulates ASC-dependent inflammasome activation. Nat Commun 5:4977
Cipriano, R; Bryson, B L; Miskimen, K L S et al. (2014) Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B. Oncogene 33:3298-306
Papp-Wallace, Krisztina M; Winkler, Marisa L; Gatta, Julian A et al. (2014) Reclaiming the efficacy of ?-lactam-?-lactamase inhibitor combinations: avibactam restores the susceptibility of CMY-2-producing Escherichia coli to ceftazidime. Antimicrob Agents Chemother 58:4290-7

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