Case Western Reserve University School of Medicine (CWRU SOM) has provided outstanding MD/PhD training since 1956. The program has a strong track record with many alumni with distinguished research careers, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training (MST) program was started in 1975 (T32 GM07250) and has 92 current students. The curriculum integrates scientific and clinical instruction with both PhD and MD course work during the first two years, personalized clinical instruction as well as research during the PhD years, core clinical clerkships, and elective time for research and clinical experiences in the final year. Criteria for acceptance include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MST program automatically admits a student to the SOM and any MST [program-affiliated PhD program, including 11 graduate programs based in the SOM plus Biomedical Engineering, Mechanical and Aerospace Engineering, Biology and Chemistry. PhD mentors are subjected to rigorous review by the MST program Steering Committee and provide individualized research training. All active mentors have established training records and are well supported by NIH research grants and other funding sources. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals of Cleveland, Cleveland Clinic Foundation, Metro Health Medical Center and the Louis Stokes Veteran's Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. All CWRU students receive full financial support for stipend, tuition and health fees for all phases of the program (8 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MST program-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities. Relevance: Overall, the program integrates clinical and scientific training of physician scientists in basic biomedical sciences and translational fields;training in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD/PhD students for outstanding careers in biomedical research to fill the national need for future physician-scientists.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Preusch, Peter C
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Case Western Reserve University
Schools of Medicine
United States
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Anderson, Ross W; Farokhniaee, AmirAli; Gunalan, Kabilar et al. (2018) Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimul 11:1140-1150
Liao, Xudong; Shen, Yuyan; Zhang, Rongli et al. (2018) Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. Proc Natl Acad Sci U S A 115:E4661-E4669
Sweet, David R; Fan, Liyan; Hsieh, Paishiun N et al. (2018) Kr├╝ppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential. Front Cardiovasc Med 5:6
Otegbeye, Folashade; Ojo, Evelyn; Moreton, Stephen et al. (2018) Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. PLoS One 13:e0191358
Shukla, Supriya; Richardson, Edward T; Drage, Michael G et al. (2018) Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes. Infect Immun 86:
Chirieleison, Steven M; Rathkey, Joseph K; Abbott, Derek W (2018) Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Sci Signal 11:
Dikina, Anna D; Alt, Daniel S; Herberg, Samuel et al. (2018) A Modular Strategy to Engineer Complex Tissues and Organs. Adv Sci (Weinh) 5:1700402
Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
McMillan, Alexandra; Nguyen, Minh Khanh; Gonzalez-Fernandez, Tomas et al. (2018) Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials 161:240-255
Jiang, Sirui; Nandy, Priya; Wang, Wenzhang et al. (2018) Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener 13:5

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