Case Western Reserve University School of Medicine (CWRU SOM) has provided outstanding MD/PhD training since 1956. The program has a strong track record with many alumni with distinguished research careers, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training Program (MSTP) was started in 1975 (T32 GM07250) and has 89 current students. The curriculum integrates scientific and clinical instruction in all three phases: both PhD and MD course work during the first two years, substantial personalized clinical instruction as well as research during the PhD years, and clinical clerkships, clinical electives and research electives in the final phase. Criteria for acceptance include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MSTP automatically admits a student to the SOM and any of the 13 MSTP-affiliated PhD programs. PhD mentors provide individualized research training. All active mentors have established training records and are well supported by NIH research grants or other funding sources. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals Case Medical Center, Cleveland Clinic, MetroHealth Medical Center and the Louis Stokes Veteran's Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. All CWRU MSTP students receive full financial support for stipend, tuition and health fees for all phases of the program (8 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MSTP-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities.

Public Health Relevance

Overall, the program integrates clinical and scientific training of physician scientists in basic and translational biomedical sciences;trainin in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD-PhD students for outstanding careers in biomedical research to fill the national need for future physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007250-39
Application #
8550274
Study Section
(TWD)
Program Officer
Preusch, Peter
Project Start
1975-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
39
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Rathkey, Joseph K; Benson, Bryan L; Chirieleison, Steven M et al. (2017) Live-cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 292:14649-14658
Liau, Brian B; Sievers, Cem; Donohue, Laura K et al. (2017) Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell 20:233-246.e7
Chung, Jooho; Ebens, Christen L; Perkey, Eric et al. (2017) Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest 127:1574-1588
Lee, Karin L; Murray, Abner A; Le, Duc H T et al. (2017) Combination of Plant Virus Nanoparticle-Based in Situ Vaccination with Chemotherapy Potentiates Antitumor Response. Nano Lett 17:4019-4028
Hsieh, Paishiun N; Zhou, Guangjin; Yuan, Yiyuan et al. (2017) A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction. Nat Commun 8:914
Nassal, Michelle M J; Wan, Xiaoping; Dale, Zack et al. (2017) Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function. Am J Physiol Heart Circ Physiol 312:H886-H895
Tong, Alexander A; Hashem, Hasan; Eid, Saada et al. (2017) Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma. Oncoimmunology 6:e1303586
Folmsbee, Stephen Sai; Gottardi, Cara J (2017) Cardiomyocytes of the Heart and Pulmonary Veins: Novel Contributors to Asthma? Am J Respir Cell Mol Biol 57:512-518
Nguyen, Minh Khanh; McMillan, Alexandra; Huynh, Cong Truc et al. (2017) Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation. J Mater Chem B 5:485-495
Tanenbaum, Joseph E; Miller, Jacob A; Alentado, Vincent J et al. (2017) Insurance status and reportable quality metrics in the cervical spine fusion population. Spine J 17:62-69

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