Case Western Reserve University School of Medicine (CWRU SOM) has provided outstanding MD/PhD training since 1956. The program has a strong track record with many alumni with distinguished research careers, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training Program (MSTP) was started in 1975 (T32 GM07250) and has 89 current students. The curriculum integrates scientific and clinical instruction in all three phases: both PhD and MD course work during the first two years, substantial personalized clinical instruction as well as research during the PhD years, and clinical clerkships, clinical electives and research electives in the final phase. Criteria for acceptance include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MSTP automatically admits a student to the SOM and any of the 13 MSTP-affiliated PhD programs. PhD mentors provide individualized research training. All active mentors have established training records and are well supported by NIH research grants or other funding sources. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals Case Medical Center, Cleveland Clinic, MetroHealth Medical Center and the Louis Stokes Veteran's Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. All CWRU MSTP students receive full financial support for stipend, tuition and health fees for all phases of the program (8 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MSTP-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities.

Public Health Relevance

Overall, the program integrates clinical and scientific training of physician scientists in basic and translational biomedical sciences;trainin in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD-PhD students for outstanding careers in biomedical research to fill the national need for future physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007250-39
Application #
8550274
Study Section
(TWD)
Program Officer
Preusch, Peter
Project Start
1975-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
39
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
McMillan, Alexandra; Nguyen, Minh Khanh; Gonzalez-Fernandez, Tomas et al. (2018) Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials 161:240-255
Jiang, Sirui; Nandy, Priya; Wang, Wenzhang et al. (2018) Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener 13:5
Tanenbaum, Joseph E; Kha, Stephanie T; Benzel, Edward C et al. (2018) The association of inflammatory bowel disease and immediate postoperative outcomes following lumbar fusion. Spine J 18:1157-1165
Elitt, Matthew S; Shick, H Elizabeth; Madhavan, Mayur et al. (2018) Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports 11:711-726
Sarvestani, Samaneh K; Signs, Steven A; Lefebvre, Veronique et al. (2018) Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9:28717-28730
Hickman, DaShawn A; Pawlowski, Christa L; Shevitz, Andrew et al. (2018) Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage. Sci Rep 8:3118
Luu, Jennings; Palczewski, Krzysztof (2018) Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A 115:2866-2872
Mamidi, Ranganath; Li, Jiayang; Doh, Chang Yoon et al. (2018) Impact of the Myosin Modulator Mavacamten on Force Generation and Cross-Bridge Behavior in a Murine Model of Hypercontractility. J Am Heart Assoc 7:e009627
Yang, Jie; Liu, Zhonghua; Wang, Chuanping et al. (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A 115:6792-6797
Borton, Anna Henry; Benson, Bryan L; Neilson, Lee E et al. (2018) Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery. J Am Heart Assoc 7:

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