This proposal requests continued funding of the predoctoral Training Program in Cell and Molecular Biology at the University of Washington and Fred Hutchinson Cancer Center (UW/FHCRC). Trainees in the program are chosen by a rigorous selection process that picks the top graduate students from three interdisciplinary programs and eight departmental programs. The major goal of this program is to train students in cell and molecular biology during their graduate career by exposing them to the wide range of research in this area. Students in the Training Program receive training beyond the standard graduate program through a monthly student presentation series that includes all of the trainees, an annual retreat that includes the trainees and their advisors, and through lectures supported by this program. This program plays an important role in training the next generation of scientists for academia and industry. The trainees have a strong record of success as shown by their publications in graduate school and the career choices they make after they leave graduate school.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007270-37
Application #
8099651
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1975-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
37
Fiscal Year
2011
Total Cost
$1,132,523
Indirect Cost
Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Calses, Philamer C; Dhillon, Kiranjit K; Tucker, Nyka et al. (2017) DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing. Cell Rep 19:162-174
Campbell, Amy E; Oliva, Jonathan; Yates, Matthew P et al. (2017) BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells. Skelet Muscle 7:16
Gorman, Jacquelyn A; Hundhausen, Christian; Errett, John S et al. (2017) The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. Nat Immunol 18:744-752
Dove, Katja K; Kemp, Hilary A; Di Bona, Kristin R et al. (2017) Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development. Proc Natl Acad Sci U S A 114:E6576-E6584
Dingens, Adam S; Haddox, Hugh K; Overbaugh, Julie et al. (2017) Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody. Cell Host Microbe 21:777-787.e4
Dove, Katja K; Olszewski, Jennifer L; Martino, Luigi et al. (2017) Structural Studies of HHARI/UbcH7?Ub Reveal Unique E2?Ub Conformational Restriction by RBR RING1. Structure 25:890-900.e5
Strauch, Eva-Maria; Bernard, Steffen M; La, David et al. (2017) Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site. Nat Biotechnol 35:667-671
Wilson, Sarah S; Bromme, Beth A; Holly, Mayumi K et al. (2017) Alpha-defensin-dependent enhancement of enteric viral infection. PLoS Pathog 13:e1006446
Brault, Michelle; Oberst, Andrew (2017) Controlled detonation: evolution of necroptosis in pathogen defense. Immunol Cell Biol 95:131-136
Dove, Katja K; Klevit, Rachel E (2017) RING-Between-RING E3 Ligases: Emerging Themes amid the Variations. J Mol Biol 429:3363-3375

Showing the most recent 10 out of 653 publications