The University of Chicago Medical Scientist Training Program (MSTP) submits this renewal application to the National Institutes of Health (NIH) to continue and expand into this century its training of outstanding leaders in the biomedical field. We request funding for 42 MSTP positions, an increase of 2 over the current recommended level of 40. At the requested level of support, NIH funding will cover approximately 20% of the program's costs, the rest being provided by institutional resources. We plan to recruit matriculating classes of 8 students who are expected to graduate in 8 years or less. The Medical Scientist Training Program at The University of Chicago Pritzker School of Medicine is in its 42nd year of uninterrupted funding and a superb training record of academic physicians in leadership positions (including current and former MSTP directorships at UCSF, Stanford, Harvard and Emory). It has graduated 227 students who have published over 2000 papers. Currently 76 individuals are enrolled in the program including 9% URM (up from 6% at our last renewal application) and 32% women. In the current cycle we have graduated or expect to graduate 44 students from the Program. Thirty-three students have entered. Continuing in the tradition of its graduates, our current MSTP students have published extensively in top journals such as Nature, Science, Cell, Immunity, Journal of Biological Chemistry, and others. In this proposal we provide compelling and detailed evidence on the superb quality of our students and the rigorous training environment at The University of Chicago which is uniquely configured to support interdisciplinary programs such as the MSTP.

Public Health Relevance

The University of Chicago Medical Scientist Training Program is designed for students who wish to pursue broad careers in research relevant to human health and disease. Overall, the MSTP seeks to fulfill a national need for individuals who will apply clinical and research experience to biomedical investigation and will catalyze the application of multidisciplinary approaches to solve the most pressing problems in medical science.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007281-38S1
Application #
8499627
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TR))
Program Officer
Preusch, Peter C
Project Start
1975-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
38
Fiscal Year
2012
Total Cost
$49,655
Indirect Cost
$2,123
Name
University of Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hsu, Phillip J; Shi, Hailing; He, Chuan (2017) Epitranscriptomic influences on development and disease. Genome Biol 18:197
Mowers, E E; Sharifi, M N; Macleod, K F (2017) Autophagy in cancer metastasis. Oncogene 36:1619-1630
Liu, Nian; Zhou, Katherine I; Parisien, Marc et al. (2017) N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res 45:6051-6063
Ranjeva, Sylvia L; Baskerville, Edward B; Dukic, Vanja et al. (2017) Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity. Proc Natl Acad Sci U S A 114:13573-13578
Jacobsen, Jennifer A; Woodard, Jennifer; Mandal, Malay et al. (2017) EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. J Immunol 198:4682-4691
Hsu, Phillip J; He, Chuan (2017) Making Changes: N6-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition. Biochemistry 56:6077-6078
Acar, Handan; Samaeekia, Ravand; Schnorenberg, Mathew R et al. (2017) Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation. Bioconjug Chem 28:2316-2326
Gao, Yihe N; Nocon, Robert S; Sharma, Ravi et al. (2017) What Factors Are Associated With Medicaid Patients' Use of Health Centers? J Prim Care Community Health 8:141-146
Uddin, Sophia; Heald, Shannon L M; Van Hedger, Stephen C et al. (2017) Understanding environmental sounds in sentence context. Cognition 172:134-143
Oh, So-Young; Lunderberg, J Mark; Chateau, Alice et al. (2017) Genes Required for Bacillus anthracis Secondary Cell Wall Polysaccharide Synthesis. J Bacteriol 199:

Showing the most recent 10 out of 363 publications