This proposal is for continuing support of the pre-doctoral training grant in biology at the Massachusetts Institute of Technology (MIT). This training grant (in its 40th year) continues to be the most important source of support for graduate students studying biological science at MIT. The mission of this program is to train the next generation of biological/biomedical scientists, many of whom will be innovators and leaders in research and education. Specifically, in this training program we strive to educate our students: to understand the fundamental underlying principles of modern biology including genetics, biochemistry, cell biology, molecular biology and quantitative data analysis; to be ethical decision makers; to flexibly adapt to the rapidly changing modern biomedical sciences landscape; to become creative, effective, rigorous researchers; to become excellent communicators of science, and to become thoughtful teachers and mentors. We seek out, recruit and train talented students from majority, underrepresented minority, and disadvantaged populations, and help them initiate successful research careers. Trainees admitted to our program have outstanding undergraduate academic records and have demonstrated strong motivation to pursue research. A key feature of our program is an intensive, focused curriculum required of all first-semester students. Students work together in lecture and discussion-style courses taught by dedicated faculty to master a fundamental set of approaches that underpin all modern molecular biological science. The training program exposes students to the research interests of all faculty members in the Biology Department prior to the critical choice of a thesis lab and topic. Responsible conduct in research is taught in three phases, including an intense mini-course for 2nd year students.
We aim to support 46 predoctoral students per year, primarily in their first and second years of training; the complete Ph.D. program takes trainees approximately 5.8 years to complete. Students' progress through the program is monitored in regular thesis committee meetings with faculty members, with oversight provided by the graduate committee. Our students perform research of outstanding quality, and most trainees go on to careers in biomedical research. Many of our former trainees are now leaders in their chosen fields.

Public Health Relevance

The MIT Department of Biology trains some of the world's most talented young scientists to unravel biology complexities fundamental to human health and disease. Our program provides training in the foundational approaches to biological research and a deep research experience in a student's chosen area. We also educate students about the basis of ethical and humane decision-making, and prepare diverse individuals for leadership positions in a range of biomedical careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007287-43
Application #
9313264
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Melillo, Amanda A
Project Start
1975-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
43
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Romer, Katherine A; de Rooij, Dirk G; Kojima, Mina L et al. (2018) Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting. Dev Biol 443:19-34
Wesselhoeft, R Alexander; Kowalski, Piotr S; Anderson, Daniel G (2018) Engineering circular RNA for potent and stable translation in eukaryotic cells. Nat Commun 9:2629
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann et al. (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361:
Phizicky, David V; Berchowitz, Luke E; Bell, Stephen P (2018) Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis. Elife 7:
Fessenden, Timothy B; Duong, Ellen; Spranger, Stefani (2018) A team effort: natural killer cells on the first leg of the tumor immunity relay race. J Immunother Cancer 6:67
Yu, Zhou; Surface, Lauren E; Park, Chong Yon et al. (2018) Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife 7:
Wyant, Gregory A; Abu-Remaileh, Monther; Frenkel, Evgeni M et al. (2018) NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science 360:751-758
Schuijers, Jurian; Manteiga, John Colonnese; Weintraub, Abraham Selby et al. (2018) Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism. Cell Rep 23:349-360
Tillman, Erik J; Richardson, Claire E; Cattie, Douglas J et al. (2018) Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics 210:1329-1337
Entova, Sonya; Billod, Jean-Marc; Swiecicki, Jean-Marie et al. (2018) Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds. Elife 7:

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