The Cellular and Molecular Biology (CMB) Graduate Program has been a free-standing PhD-granting program at the University of Michigan for almost thirty-five years.
The aim of this Program is to train students with a broad perspective in cellular and molecular biosciences. It is one of the most popular graduate programs in biomedical sciences at Michigan, and during the past 5 years, 81 new students entered the Program and 69 others received PhD's. The University-wide CMB Program draws on faculty, courses and research facilities from 20 departments in the Schools of Medicine, Dentistry, Engineering and the College of Literature Sciences and the Arts. This diversity of expertise and opportunity allows students the broadest possible choice in terms of both elective coursework and strong research training environments. At the same time, students in the Program share a core of common training experiences through a flexible program of required and elective coursework, a strong student seminar program, student-organized short courses, an annual symposium and poster session, an annual retreat, social events and service to the Program. CMB events provide cohesiveness for the Program and contribute to the intellectual environment of the University as highly regarded and well-attended scientific activities. Research programs in the laboratories of the 151 faculty members in CMB cover a wide range of disciplines, including: genetics, genomics, gene regulation;cell biology, biochemistry, physiology and structure;microbial pathogenesis and immunology;developmental biology, neurobiology, aging;molecular mechanisms and genetics of disease. The CMB Program is the only entity at the University that provides training in such diverse problems and perspectives, encouraging interdisciplinary approaches to both basic and translational biomedical research. The continuing growth of the CMB Program reflects increasing interest in its interdisciplinary approach, and highlights its unique role in the context of the Program in Biomedical Sciences at the University. This proposal requests support for 20 trainees, with the aim of supporting 10 students per year for two years. The current goal is to maintain the vitality of the CMB Program while retaining the high quality and individualized training for which CMB is known, and to train leaders of the next generation of biomedical researchers.

Public Health Relevance

The research performed by students in the CMB Program directly addresses problems in both fundamental and clinical sciences that have important implications for a broad array of public health problems, including cancer, chronic (e.g. diabetes, rheumatoid arthritis), infectious (e.g. AIDS, mycobacterial) and neurodegenerative (e.g. Parkinson's, Alzheimer's) diseases. Further, training students who apply cellular and molecular approaches to a wide variety of scientific disciplines continues to add to the population of outstanding scientists in academic and applied research whose work advances knowledge in a wide range of areas important for human health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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Breznau, Elaina B; Murt, Megan; Blasius, T Lynne et al. (2017) The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis. J Cell Sci 130:1809-1821
Lang, Sarah E; Stevenson, Tamara K; Schatz, Tabea M et al. (2017) Functional communication between PKC-targeted cardiac troponin I phosphorylation sites. Arch Biochem Biophys 627:1-9
Mann, J E; Hoesli, R; Michmerhuizen, N L et al. (2017) Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC. J Cancer 8:332-344
Cunningham, Corey N; He, Kaiyu; Arunagiri, Anoop et al. (2017) Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes 66:741-753
Sebastian, Nadia T; Zaikos, Thomas D; Terry, Valeri et al. (2017) CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog 13:e1006509
Neal, Lori M; Qiu, Yafeng; Chung, Jooho et al. (2017) T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection. J Immunol 199:643-655
Mesler, Arlee L; Veniaminova, Natalia A; Lull, Madison V et al. (2017) Hair Follicle Terminal Differentiation Is Orchestrated by Distinct Early and Late Matrix Progenitors. Cell Rep 19:809-821
Zhang, Yaqing; Velez-Delgado, Ashley; Mathew, Esha et al. (2017) Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut 66:124-136
Janssens, Derek H; Hamm, Danielle C; Anhezini, Lucas et al. (2017) An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division. Dev Cell 40:367-380.e7
Niknafs, Yashar S; Pandian, Balaji; Iyer, Hariharan K et al. (2017) TACO produces robust multisample transcriptome assemblies from RNA-seq. Nat Methods 14:68-70

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