This application will support and renew the Medical Scientist Training Program (MSTP) at Stanford University School of Medicine. In 42 years of continuous NIH funding, 248 trainees have graduated from this program, many of whom have become leaders in their fields of academic medicine and biomedical research. Our program provides a superb environment and unique advantages for fulfilling our mission "to train pioneering physician-scientists dedicated to a lifetime of biomedical discovery that improves human health through innovation". Dual degree pre-doctoral training in the Stanford MSTP benefits from many established strengths, including (1) a University campus with adjacent Schools of Medicine, Engineering, and Humanities &Sciences whose setting and facilities encourage interdisciplinary investigations;(2) a world-class faculty devoted to biomedical research and mentoring;(3) a diverse, accomplished medical student body selected from a highly qualified applicant pool and attracted by a curriculum whose centerpiece is the Scholarly Concentration Program, and supported by institutional resources including the new Knowledge and Learning Center;and (4) clinical training programs in a diversity of settings, including tertiary care, county hospital, Veterans Administration Hospital, HMO and community outpatient clinics. These and other strengths have durably produced successful outcomes in our trainees, based on several metrics used to compare MD- PhD programs nationally, including low attrition, time to degree conferral, publication record, and high retention of graduates in biomedical research careers. This proposal also describes important changes in the Stanford program structure that are highly responsive to concerns raised in the last review of our MSTP. These program enhancements include a significantly increased level of institutional support, reflected in increased staffing and faculty effort to direct the MSTP;increased financial support for student training by the School of Medicine;periodic internal and external program evaluation;creation and implementation of MSTP-specific innovative courses and teaching programs;improved mentoring and monitoring mechanisms for students throughout their training;increased faculty participation;and enhanced vertical integration among trainees. Together, the increased institutional support, increased effort by School of Medicine faculty and leadership, dedicated program enhancements, and integration of clinical and graduate training have changed, expanded and improved the Stanford MSTP. The number of dual-degree students trained and supported by the MSTP more than quadruples the number of trainee positions provided by the NIGMS T32. Support through this proposal, leveraged with School of Medicine resources, will support continuing innovation in training physician scientists at Stanford devoted to improving human health through a lifetime of biomedical research.
Continued improvement in human health depends on the translation of fundamental knowledge to clinical settings, and the integration of approaches from several different disciplines. The Stanford MSTP embraces and promotes these goals, training physician- scientists to be academic leaders for future advances in biomedical research.
|Lo, Nathan C; Addiss, David G; Hotez, Peter J et al. (2016) A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now. Lancet Infect Dis :|
|Tevlin, R; Walmsley, G G; Marecic, O et al. (2016) Stem and progenitor cells: advancing bone tissue engineering. Drug Deliv Transl Res 6:159-73|
|Loh, Kyle M; Chen, Angela; Koh, Pang Wei et al. (2016) Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell 166:451-67|
|Chen, James Y; Miyanishi, Masanori; Wang, Sean K et al. (2016) Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature 530:223-7|
|Weiskopf, Kipp; Jahchan, Nadine S; Schnorr, Peter J et al. (2016) CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J Clin Invest 126:2610-20|
|Rosenberg, Jacob M; Price, Jordan V; Barcenas-Morales, Gabriela et al. (2016) Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency. J Allergy Clin Immunol 137:204-13.e3|
|Weiskopf, Kipp; Schnorr, Peter J; Pang, Wendy W et al. (2016) Myeloid Cell Origins, Differentiation, and Clinical Implications. Microbiol Spectr 4:|
|Lee, Jung-Rok; Haddon, D James; Wand, Hannah E et al. (2016) Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. Sci Rep 6:27623|
|Rengarajan, Michelle; Hayer, Arnold; Theriot, Julie A (2016) Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS Pathog 12:e1005603|
|Carmi, Yaron; Prestwood, Tyler R; Spitzer, Matthew H et al. (2016) Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight 1:e89020|
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