This is a proposal for the continued training of predoctoral graduate students in the area of molecular and cell biology. The overall guiding principle is to support students from'Training Grant funds who are the most talented and productive. Our objective is to develop their skills as researchers in the general area of cell biology, but we aim to train them more broadly in all aspects of doing research (e.g.giving seminars, writing grants) so that they will go on to be successful in the academy or in research institutions. The program is comprised of 45 Trainer-directed research programs and 15 Trainee positions for graduate students, who will do their dissertation research in the Trainer labs. The graduate students are recruited primarily from four graduate programs (known as Graduate Groups), namely Biochemistry &Molecular Biology, Cell &Developmental Biology, Genetics and Microbiology, and are generally appointed to the Training Grant after their second year in the graduate program. The program is administered by a nine- person Executive Committee, including a student member. The Training faculty will provide research guidance and mentoring in their labs, will be actively involved in recruiting graduate students to the Davis campus, and will offer courses in molecular and cell biology. In the last five years, the Training faculty have placed particular emphasis on the recruitment of under-represented minority students to our program. Currently there is (andwill be) a highly successful training program external seminar series in which extramural speakers are selected and hosted by the Trainees;an Annual Research Retreat, which is held at Lake Tahoe and serves as a forum for presentation of research seminars by students, postdocs and faculty;brown-bag lunches for the Trainees with the Executive Committee to present and discuss their research;a required course in the responsible conduct of research;and quarterly workshops for all current and past trainees in various areas of career development, such as instruction in grant writing.

Public Health Relevance

All of our students will be working in labs where fundamental cellularprocesses are studied at the molecular level, and where the ultimate goal is to understand these processes in the context of human disease. All trainees will take a course in translational research being developed in collaboration with two other training grants on campus in translational research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007377-34
Application #
8290533
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1983-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
34
Fiscal Year
2012
Total Cost
$385,248
Indirect Cost
$23,348
Name
University of California Davis
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Vlahakis, Ariadne; Graef, Martin; Nunnari, Jodi et al. (2014) TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy. Proc Natl Acad Sci U S A 111:10586-91
Bone, Courtney R; Tapley, Erin C; Gorjánácz, Mátyás et al. (2014) The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration. Mol Biol Cell 25:2853-65
Speca, D J; Ogata, G; Mandikian, D et al. (2014) Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Genes Brain Behav 13:394-408
Mandikian, Danielle; Bocksteins, Elke; Parajuli, Laxmi Kumar et al. (2014) Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors. J Comp Neurol 522:3555-74
Andaya, Armann; Villa, Nancy; Jia, Weitao et al. (2014) Phosphorylation stoichiometries of human eukaryotic initiation factors. Int J Mol Sci 15:11523-38
Chitwood, Daniel H; Ranjan, Aashish; Kumar, Ravi et al. (2014) Resolving distinct genetic regulators of tomato leaf shape within a heteroblastic and ontogenetic context. Plant Cell 26:3616-29
Öze?, Ali R; Feoktistova, Kateryna; Avanzino, Brian C et al. (2014) Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicases. Nat Protoc 9:1645-61
Smaldone, Gregory T; Jin, Yujie; Whitfield, Damion L et al. (2014) Growth of Myxococcus xanthus in continuous-flow-cell bioreactors as a method for studying development. Appl Environ Microbiol 80:2461-7
Parales, Rebecca E; Nesteryuk, Vasyl; Hughes, Jonathan G et al. (2014) Cytosine chemoreceptor McpC in Pseudomonas putida F1 also detects nicotinic acid. Microbiology 160:2661-9
Hahm, Johnnie B; Schroeder, Amy C; Privalsky, Martin L (2014) The two major isoforms of thyroid hormone receptor, TR?1 and TR?1, preferentially partner with distinct panels of auxiliary proteins. Mol Cell Endocrinol 383:80-95

Showing the most recent 10 out of 140 publications