The Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program has trained over 550 scientists since 1979. Serving as the major training program for seven basic science departments at the Johns Hopkins University School of Medicine, BCMB is one of the oldest multidisciplinary graduate programs in the country. There are 100 faculty members actively involved in research, teaching and as mentors. The Departments that participate in the program include Biological Chemistry, Biophysics and Biophysical Chemistry, Cell Biology, Molecular Biology and Genetics, Neuroscience, Pharmacology and Molecular Sciences, and Physiology. The objective of the BCMB program is to provide trainees with a breadth of understanding in basic biomedical science to ultimately prepare them for independent and productive careers. An average of 23 students per year matriculate in the program. During the first three-quarters of the first year, students take a unified, rigorous curriculum (Foundations of Modern Biology) that includes modules in biophysics, macromolecular structure and analysis, molecular biology and genomics, genetics, bioinformatics, organic mechanisms in biology, cell structure and dynamics, and pathways and regulation, as well as a paper discussion module that parallels the core course. In the last quarter, students choose three short electives in areas of interest;most of these are small discussion-based courses. A Research Ethics and Career Issues course is also taken in the fourth quarter. A final component of the first year is three laboratory rotations, with poster and oral presentations at the completion of the first two rotations. Second year students take a single course (Method and Logic), and then the qualifying oral exam. Students choose a laboratory for thesis work at the end of their first year, and participate in that department's seminars and journal clubs, as well as complete four additional electives over the course of their training. Most students publish multiple research papers, and the training concludes with presentation of a public seminar and submission of the doctoral thesis. BCMB graduates hold leadership positions at all levels of academia, government and industry. The success of our students is fostered by an extraordinary level of collaboration and interaction among the faculty and trainees in the various laboratories. Special emphasis is placed on applying conceptual breakthroughs in basic science to problems relevant to human health and disease. As such, our trainees have made important advances in areas ranging from cancer to infectious disease, diabetes, neurodegeneration, mental retardation, pain management, cardiovascular disease and many others.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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Johns Hopkins University
Anatomy/Cell Biology
Schools of Medicine
United States
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Huebner, Robert J; Ewald, Andrew J (2014) Cellular foundations of mammary tubulogenesis. Semin Cell Dev Biol 31:124-31
Cieniewicz, Anne M; Moreland, Linley; Ringel, Alison E et al. (2014) The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3. Mol Cell Proteomics 13:2896-910
Gilbert, Tonya M; McDaniel, Stephen L; Byrum, Stephanie D et al. (2014) A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Mol Cell Proteomics 13:2883-95
Smith, Jessica M; Warrington, Nicole V; Vierling, Ryan J et al. (2014) Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate. J Antibiot (Tokyo) 67:77-83
Debeljak, Marija; Freed, Donald N; Welch, Jane A et al. (2014) Haplotype counting by next-generation sequencing for ultrasensitive human DNA detection. J Mol Diagn 16:495-503
Stine, Rachel R; Greenspan, Leah J; Ramachandran, Kapil V et al. (2014) Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis. PLoS Genet 10:e1004713
Guzzo, Catherine M; Ringel, Alison; Cox, Eric et al. (2014) Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198. PLoS One 9:e105271
Schaughency, Paul; Merran, Jonathan; Corden, Jeffry L (2014) Genome-wide mapping of yeast RNA polymerase II termination. PLoS Genet 10:e1004632
Papazyan, Romeo; Voronina, Ekaterina; Chapman, Jessica R et al. (2014) Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis. Elife 3:e02996
Paix, Alexandre; Wang, Yuemeng; Smith, Harold E et al. (2014) Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans. Genetics 198:1347-56

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