The goal of this program is to train graduate students for the Ph.D. degree in the broad and interdisciplinary areas of Cell Biology, Molecular Biology and Genetics. This program includes 62 training faculty from 8 basic science departments, and is the only graduate training program at Einstein with this broad and interdisciplinary research emphasis. This renewal application is to continue the program with support for 20 trainees (6-7 trainees appointed per year). Over the past 10 years, the program has graduated 45 Ph.D. students, with more than 90% continuing in science-related careers. The overall objectives of the program are for students to perform significant basic science research projects, to acquire rigorous scientific background and experimental training, and to develop into independent scientists that make long-term contributions. The program is uniquely suited to train students in the use of a wide variety of cell biology, molecular biology, biochemical and genetic methods to address fundamental basic science questions. It is also ideally positioned to promote interdisciplinary research and quantitative methodologies. Training faculty are selected based on their research excellence in the broad areas of Cell Biology, Molecular Biology and Genetics, and their commitment to mentoring graduate students and to providing an excellent training environment. All but the most junior faculty members have substantial mentoring experience. A number of mechanisms are in place to assist junior faculty in mentoring students and to provide additional oversight for students in their labs. Trainees complete 2-3 research rotations in the first year, and undertake rigorous coursework including several foundation courses taught by our trainers. Students write a grant proposal-type qualifying exam based on their Ph.D. research and defend it orally to an interdisciplinary faculty committee. Students are reviewed by the steering committee after the first and second year of graduate training, and interviewed by the Program Director prior to appointment for 2-3 years of funding. A number of training program activities are used to build a coherent training effort in which students participate until completion of the Ph.D. Trainees present yearly in a very active work-in- progress series and host an annual seminar speaker. A yearly program retreat includes talks by more senior students and ethics discussions. Former trainees also frequently present in the retreat to provide career perspectives. At all of these events, our trainers and steering committee, together with the Director, provide input on research directions, presentation skills, and publication strategies. Together, these features make the program a vibrant and highly interactive community of faculty trainers and graduate students involved in key basic science questions that are relevant to human health. Students graduate with the scientific background, research skills, and critical thought process necessary for an independent career in science.

Public Health Relevance

This is a renewal of a training grant that supports pre-doctoral students engaged in research in Cell Biology, Molecular Biology and Genetics. This basic research has many important applications to human health issues including cancer, developmental problems, diabetes, and infectious disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007491-37
Application #
8492091
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1987-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
37
Fiscal Year
2013
Total Cost
$759,128
Indirect Cost
$36,084
Name
Albert Einstein College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
McKimpson, Wendy M; Zheng, Min; Chua, Streamson C et al. (2017) ARC is essential for maintaining pancreatic islet structure and ?-cell viability during type 2 diabetes. Sci Rep 7:7019
Warren, Christopher; Shechter, David (2017) Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches. J Mol Biol 429:2401-2426
Saied-Santiago, Kristian; Townley, Robert A; Attonito, John D et al. (2017) Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Genetics 206:1951-1967
Miskolci, Veronika; Hodgson, Louis; Cox, Dianne (2017) Using Fluorescence Resonance Energy Transfer-Based Biosensors to Probe Rho GTPase Activation During Phagocytosis. Methods Mol Biol 1519:125-143
Riascos-Bernal, Dario F; Chinnasamy, Prameladevi; Gross, Jordana N et al. (2017) Inhibition of Smooth Muscle ?-Catenin Hinders Neointima Formation After Vascular Injury. Arterioscler Thromb Vasc Biol 37:879-888
Hanna, Samer J; McCoy-Simandle, Kessler; Miskolci, Veronika et al. (2017) The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis. Sci Rep 7:8547
Donnelly, Sara K; Cabrera, Ramon; Mao, Serena P H et al. (2017) Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol 216:4331-4349
Guthrie, Leah; Gupta, Sanchit; Daily, Johanna et al. (2017) Human microbiome signatures of differential colorectal cancer drug metabolism. NPJ Biofilms Microbiomes 3:27
Bhérer, Claude; Campbell, Christopher L; Auton, Adam (2017) Refined genetic maps reveal sexual dimorphism in human meiotic recombination at multiple scales. Nat Commun 8:14994
Sugi, Tatsuki; Tu, Vincent; Ma, Yanfen et al. (2017) Toxoplasma gondii Requires Glycogen Phosphorylase for Balancing Amylopectin Storage and for Efficient Production of Brain Cysts. MBio 8:

Showing the most recent 10 out of 255 publications