Continuing support is requested for Yale's Predoctoral Training Program in Genetics. The program involves 57 trainers from a total of 11 different departments. The principal administrative and training entities are the Departments of Molecular, Cellular and Developmental Biology (MCDB) and Ecology and Evolutionary Biology (EEB) in the Yale University Faculty of Arts and Sciences, and the Department of Genetics in the Yale University School of Medicine. The numbers of graduate students currently enrolled in the primary participating departments are 79 (MCDB), 53 (Genetics) and 29 (EEB). Students in the Departments of MCDB and Genetics enter the university through the interdepartmental Combined Program in the Biological and Biomedical Sciences (BBS). Most incoming trainees have a Bachelor's degree in biology or biochemistry. Admission is granted to trainees whose graduate record exam scores and grade point averages are high. Particular attention is paid to research accomplishments and letters of recommendation from scientists with whom the trainee has done research. The program offers training in all aspects of modern genetics, including clinical genetics, genomics and bioinformatics, developmental genetics, immunogenetics, cancer genetics, evolutionary and population genetics. Students have the opportunity to work with a variety of model organisms, including Drosophila, C. elegans, yeast, Arabidopsis, maize, E. coli, viruses and mice. Training in the first year includes formal course work and research rotations. In the second year, students continue course work and begin thesis research. As part of the qualifying exam administered in year two, each student is expected to demonstrate mastery in a number of broad topic areas and to prepare and defend one or more research proposals. Later years are devoted to thesis research and preparation of a dissertation. All students receive supervised teaching experience. The majority of graduates go on to do postdoctoral research, and many of these subsequently obtain independent positions at academic and research institutions. In addition, many graduates obtain research positions in biotechnology and pharmaceutical companies. Funds are requested to support 18 graduate students per year for a five-year period

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (CG))
Program Officer
Haynes, Susan R
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Arts and Sciences
New Haven
United States
Zip Code
Chow, Ryan D; Guzman, Christopher D; Wang, Guangchuan et al. (2017) AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nat Neurosci 20:1329-1341
Delventhal, R; Menuz, K; Joseph, R et al. (2017) The taste response to ammonia in Drosophila. Sci Rep 7:43754
Park, Sangbum; Gonzalez, David G; Guirao, Boris et al. (2017) Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat Cell Biol 19:155-163
Schwalm 3rd, Nathan D; Townsend 2nd, Guy E; Groisman, Eduardo A (2017) Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron. Mol Microbiol 104:32-45
Xin, Daisy; Christopher, Kasey J; Zeng, Lewie et al. (2017) IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture. Development 144:1544-1553
Chezem, William R; Memon, Altamash; Li, Fu-Shuang et al. (2017) SG2-Type R2R3-MYB Transcription Factor MYB15 Controls Defense-Induced Lignification and Basal Immunity in Arabidopsis. Plant Cell 29:1907-1926
Elison, Gregory L; Song, Ruijie; Acar, Murat (2017) A Precise Genome Editing Method Reveals Insights into the Activity of Eukaryotic Promoters. Cell Rep 18:275-286
Liu, Ping; Song, Ruijie; Elison, Gregory L et al. (2017) Noise reduction as an emergent property of single-cell aging. Nat Commun 8:680
Mano, Omer; Clark, Damon A (2017) Graphics Processing Unit-Accelerated Code for Computing Second-Order Wiener Kernels and Spike-Triggered Covariance. PLoS One 12:e0169842
Fischer, Caleb N; Trautman, Eric P; Crawford, Jason M et al. (2017) Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. Elife 6:

Showing the most recent 10 out of 123 publications