Over the last ten years, the world has witnessed unprecedented advances in biomedical research and discovery. We have observed technological miracles including isolation of human embryonic stem cells, completion of the human genome project, generation of new heart valves from stem cells and the discovery of novel genetic risk factors through genome-wide screens. With the rapid development and application of new technologies to biomedical research, enormous progress has been made in understanding basic human biology and disease. In contrast, the translation of this knowledge to the discovery, development and optimal use of pharmacological therapies has been slow. This slow progress can be attributed, in large part, to a severe shortage of well-trained, qualified clinical pharmacology investigators nationally who can fulfill this need for translational research and, paradoxically, a marked contraction of training opportunities within the U.S. At UCSF, we are keenly aware of what has been described as an "overwhelming mandate" to train the next generation of clinical pharmacologist researchers. For the past 30 years, the Clinical Pharmacology Training program at UCSF has consistently produced clinical pharmacologists of the highest caliber. Therefore, our UCSF training program is in an excellent position to "address (this) unfortunate shortage of qualified investigators in the field" by developing a well-trained and diverse contingent of clinical-scientist investigators who will serve as tomorrow's leaders in clinical pharmacology research and practice in academia as well as the pharmaceutical and biotechnology industries. We recognize the strengths of our faculty and clinical institutions and believe strongly that we are uniquely positioned to fulfill the growing and evolving dynamic needs of adult and pediatric clinical pharmacology through the recruitment of an expanded group of diverse and highly-motivated M.D., Pharm.D. and Ph.D. fellows into our research-intensive Clinical Pharmacology post-doctoral fellowship program. We propose to continue and expand our training program to educate and develop highly qualified researchers in modern clinical pharmacology. These scientists will be leaders in the translation of basic discoveries to clinical research and patient care. Herein, we describe the continuation and expansion of our training program with an emphasis on new developments including new leadership and expanded research and training directions.
There is a severe shortage of qualified clinical pharmacology investigators who can translate advances in biomedical research to the discovery, development and use of pharmacological therapies. The UCSF Clinical Pharmacology Training Program will address this shortage by educating and developing highly qualified researchers in modern clinical pharmacology.
|Pino-Yanes, Maria; Thakur, Neeta; Gignoux, Christopher R et al. (2015) Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol 135:228-35|
|Sampson, Mario R; Frymoyer, Adam; Rattray, Benjamin et al. (2014) Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. Ther Drug Monit 36:584-9|
|Myers, Rachel A; Scott, Nicole M; Gauderman, W James et al. (2014) Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet 23:5251-9|
|Province, M A; Goetz, M P; Brauch, H et al. (2014) CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. Clin Pharmacol Ther 95:216-27|
|Thakur, Neeta; Martin, Melissa; Castellanos, Elizabeth et al. (2014) Socioeconomic status and asthma control in African American youth in SAGE II. J Asthma 51:720-8|
|Moreno-Estrada, Andrés; Gignoux, Christopher R; Fernández-López, Juan Carlos et al. (2014) Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science 344:1280-5|
|Frymoyer, Adam; Meng, Lina; Bonifacio, Sonia L et al. (2013) Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia. Pharmacotherapy 33:718-26|
|Yee, Sook Wah; Nguyen, Anh Nguyet; Brown, Chaline et al. (2013) Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci 102:3451-7|
|Nishimura, Katherine K; Galanter, Joshua M; Roth, Lindsey A et al. (2013) Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am J Respir Crit Care Med 188:309-18|
|Lorizio, Wendy; Wu, Alan H B; Beattie, Mary S et al. (2012) Clinical and biomarker predictors of side effects from tamoxifen. Breast Cancer Res Treat 132:1107-18|
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